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    TPI1 triosephosphate isomerase 1 [ Homo sapiens (human) ]

    Gene ID: 7167, updated on 2-Aug-2021

    Summary

    Official Symbol
    TPI1provided by HGNC
    Official Full Name
    triosephosphate isomerase 1provided by HGNC
    Primary source
    HGNC:HGNC:12009
    See related
    Ensembl:ENSG00000111669 MIM:190450
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIM; TPI; TPID; HEL-S-49
    Summary
    This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in heart (RPKM 181.7), brain (RPKM 179.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TPI1 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6866834..6870948)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6976584..6980112)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 3 Neighboring gene cell division cycle associated 3 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene uncharacterized LOC105369632 Neighboring gene ribosomal protein L13 pseudogene 5 Neighboring gene DSTN pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of triosephosphate isomerase 1 (TPI1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC88108

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables methylglyoxal synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triose-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables triose-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triose-phosphate isomerase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables triose-phosphate isomerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glyceraldehyde-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glyceraldehyde-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylglyoxal biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    triosephosphate isomerase
    Names
    epididymis secretory protein Li 49
    methylglyoxal synthase
    triose-phosphate isomerase
    NP_000356.1
    NP_001152759.1
    NP_001244955.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011948.1 RefSeqGene

      Range
      5112..8529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1126

    mRNA and Protein(s)

    1. NM_000365.6NP_000356.1  triosephosphate isomerase isoform 1

      See identical proteins and their annotated locations for NP_000356.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AK222638, BC009329, DB444195, U47924
      Consensus CDS
      CCDS8566.1
      UniProtKB/Swiss-Prot
      P60174
      UniProtKB/TrEMBL
      Q53HE2, V9HWK1
      Related
      ENSP00000379933.4, ENST00000396705.10
      Conserved Domains (1) summary
      PTZ00333
      Location:2247
      PTZ00333; triosephosphate isomerase; Provisional
    2. NM_001159287.1NP_001152759.1  triosephosphate isomerase isoform 2

      See identical proteins and their annotated locations for NP_001152759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The resulting isoform has a longer N-terminus compared to isoform 1.
      Source sequence(s)
      DB444195, M10036, U47924
      Consensus CDS
      CCDS53740.1
      UniProtKB/Swiss-Prot
      P60174
      Related
      ENSP00000484435.1, ENST00000613953.4
      Conserved Domains (1) summary
      PTZ00333
      Location:39284
      PTZ00333; triosephosphate isomerase; Provisional
    3. NM_001258026.2NP_001244955.1  triosephosphate isomerase isoform 3

      See identical proteins and their annotated locations for NP_001244955.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK298809, AW250466, U47924
      Consensus CDS
      CCDS58206.1
      UniProtKB/Swiss-Prot
      P60174
      Related
      ENSP00000443599.1, ENST00000535434.5
      Conserved Domains (1) summary
      cl21457
      Location:1165
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      6866834..6870948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_002957378.1 RNA Sequence

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