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    Mcm9 minichromosome maintenance 9 homologous recombination repair factor [ Mus musculus (house mouse) ]

    Gene ID: 71567, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mcm9provided by MGI
    Official Full Name
    minichromosome maintenance 9 homologous recombination repair factorprovided by MGI
    Primary source
    MGI:MGI:1918817
    See related
    Ensembl:ENSMUSG00000058298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm235; Mcmdc1; 9030408O17Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.4), liver E14 (RPKM 2.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mcm9 in Genome Data Viewer
    Location:
    10; 10 B3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (53536315..53630627, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (53257130..53350245, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36280 Neighboring gene predicted gene, 20597 Neighboring gene predicted gene, 40650 Neighboring gene predicted gene 3902 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene mannosidase 1, alpha Neighboring gene predicted gene, 16998

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC70158

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    MutLbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    MutSbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    NOT DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    recombinational interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    MCM8-MCM9 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MCM8-MCM9 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA helicase MCM9
    Names
    DNA replication licensing factor MCM9
    mini-chromosome maintenance deficient 9
    mini-chromosome maintenance deficient domain-containing protein 1
    minichromosome maintenance complex component 9
    XP_006512919.1
    XP_006512920.1
    XP_011241508.1
    XP_017169586.1
    XP_017169587.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027830.3NP_082106.3  DNA helicase MCM9

      Status: VALIDATED

      Source sequence(s)
      AC153949, AC155941
      Consensus CDS
      CCDS23846.1
      Related
      ENSMUSP00000074978.5, ENSMUST00000075540.6
      Conserved Domains (2) summary
      COG1241
      Location:10605
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      cl25751
      Location:7391004
      DUF4045; Domain of unknown function (DUF4045)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      53536315..53630627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314097.1XP_017169586.1  DNA helicase MCM9 isoform X1

      UniProtKB/Swiss-Prot
      Q2KHI9
      Conserved Domains (2) summary
      COG1241
      Location:10605
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      cl25751
      Location:7391004
      DUF4045; Domain of unknown function (DUF4045)
    2. XM_017314098.1XP_017169587.1  DNA helicase MCM9 isoform X2

      Conserved Domains (1) summary
      pfam00493
      Location:30249
      MCM; MCM2/3/5 family
    3. XM_011243206.1XP_011241508.1  DNA helicase MCM9 isoform X3

      See identical proteins and their annotated locations for XP_011241508.1

      Conserved Domains (1) summary
      pfam00493
      Location:10230
      MCM; MCM2/3/5 family
    4. XM_006512857.3XP_006512920.1  DNA helicase MCM9 isoform X5

      Conserved Domains (3) summary
      COG1241
      Location:10383
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:13128
      MCM_N; MCM N-terminal domain
      cl21455
      Location:347385
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. XM_006512856.3XP_006512919.1  DNA helicase MCM9 isoform X4

      Conserved Domains (3) summary
      COG1241
      Location:10383
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:13128
      MCM_N; MCM N-terminal domain
      cl21455
      Location:347375
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_380074.3 RNA Sequence

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