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    Arhgap21 Rho GTPase activating protein 21 [ Mus musculus (house mouse) ]

    Gene ID: 71435, updated on 21-Apr-2024

    Summary

    Official Symbol
    Arhgap21provided by MGI
    Official Full Name
    Rho GTPase activating protein 21provided by MGI
    Primary source
    MGI:MGI:1918685
    See related
    Ensembl:ENSMUSG00000036591 AllianceGenome:MGI:1918685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARHGAP10; 5530401C11Rik
    Summary
    Predicted to enable GTPase activator activity. Acts upstream of or within regulation of endocytosis. Located in plasma membrane. Is expressed in nervous system and neural retina. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 9.5), CNS E14 (RPKM 6.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2 A3; 2 14.6 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (20852746..20973761, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (20847919..20968691, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene enhancer trap locus 4 Neighboring gene STARR-seq mESC enhancer starr_03841 Neighboring gene predicted gene 17171 Neighboring gene STARR-seq mESC enhancer starr_03842 Neighboring gene predicted gene, 54104 Neighboring gene STARR-seq mESC enhancer starr_03843 Neighboring gene STARR-seq mESC enhancer starr_03846 Neighboring gene CRISPRi-validated Etl4 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_03863 Neighboring gene STARR-seq mESC enhancer starr_03867 Neighboring gene STARR-seq mESC enhancer starr_03870 Neighboring gene STARR-positive B cell enhancer mm9_chr2:20885831-20886131 Neighboring gene STARR-positive B cell enhancer ABC_E5897 Neighboring gene STARR-seq mESC enhancer starr_03884 Neighboring gene STARR-seq mESC enhancer starr_03887 Neighboring gene VISTA enhancer mm1447 Neighboring gene predicted gene 13375 Neighboring gene STARR-seq mESC enhancer starr_03890 Neighboring gene phosphoribosyltransferase domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03891 Neighboring gene enkurin, TRPC channel interacting protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of Golgi location ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 21
    Names
    rho GTPase-activating protein 10
    rho-type GTPase-activating protein 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081364.4NP_001074833.3  rho GTPase-activating protein 21 isoform 2

      See identical proteins and their annotated locations for NP_001074833.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AL773540, AL929100, BX649226
      Consensus CDS
      CCDS38054.2
      UniProtKB/TrEMBL
      B2RWX1, B7ZCJ0
      Related
      ENSMUSP00000133851.2, ENSMUST00000173194.8
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11381333
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9271036
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    2. NM_001128084.3NP_001121556.2  rho GTPase-activating protein 21 isoform 1

      See identical proteins and their annotated locations for NP_001121556.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL773540, AL929100, BX649226
      Consensus CDS
      CCDS50512.1
      UniProtKB/TrEMBL
      B2RWX1, B7ZCJ1
      Related
      ENSMUSP00000120357.3, ENSMUST00000141298.9
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11481343
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9371046
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    3. NM_001408319.1NP_001395248.1  rho GTPase-activating protein 21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL773540, AL929100, BX649226
      UniProtKB/TrEMBL
      B7ZCJ1
    4. NM_001408320.1NP_001395249.1  rho GTPase-activating protein 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL773540, AL929100, BX649226
      UniProtKB/TrEMBL
      B7ZCJ0
    5. NM_001408321.1NP_001395250.1  rho GTPase-activating protein 21 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929100, BX649226
    6. NM_001408322.1NP_001395251.1  rho GTPase-activating protein 21 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929100, BX649226
    7. NM_001408323.1NP_001395252.1  rho GTPase-activating protein 21 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773540, AL929100, BX649226
    8. NM_001408324.1NP_001395253.1  rho GTPase-activating protein 21 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL773540, AL929100, BX649226
      Related
      ENSMUSP00000133347.2, ENSMUST00000174584.8
    9. NM_001408325.1NP_001395254.1  rho GTPase-activating protein 21 isoform 7

      Status: VALIDATED

      Source sequence(s)
      BX649226

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      20852746..20973761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252084.2XP_030107944.1  rho GTPase-activating protein 21 isoform X6

      UniProtKB/TrEMBL
      B2RWX1
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11391334
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9271036
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    2. XM_006497540.5XP_006497603.1  rho GTPase-activating protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006497603.1

      UniProtKB/TrEMBL
      B2RWX1
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11491344
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9371046
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    3. XM_006497539.5XP_006497602.1  rho GTPase-activating protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006497602.1

      UniProtKB/TrEMBL
      B2RWX1
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11491344
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9371046
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    4. XM_006497541.4XP_006497604.1  rho GTPase-activating protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006497604.1

      UniProtKB/TrEMBL
      B2RWX1
      Conserved Domains (3) summary
      cd00992
      Location:54161
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11491344
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9371046
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    5. XM_006497542.5XP_006497605.1  rho GTPase-activating protein 21 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MQE8
      Conserved Domains (3) summary
      cd00992
      Location:55162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11491344
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9381047
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    6. XM_017319262.3XP_017174751.1  rho GTPase-activating protein 21 isoform X10

      UniProtKB/TrEMBL
      G3UWM5
      Conserved Domains (3) summary
      cd00992
      Location:55162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11491344
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9381047
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    7. XM_006497538.5XP_006497601.1  rho GTPase-activating protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQE8
      Conserved Domains (3) summary
      cd00992
      Location:55162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11501345
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9381047
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    8. XM_011238986.4XP_011237288.1  rho GTPase-activating protein 21 isoform X9

      UniProtKB/TrEMBL
      G3UWM5
      Conserved Domains (3) summary
      cd00992
      Location:55162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11501345
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9381047
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    9. XM_017319263.3XP_017174752.1  rho GTPase-activating protein 21 isoform X11

      UniProtKB/TrEMBL
      G3UWM5
      Conserved Domains (3) summary
      cd00992
      Location:55162
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01253
      Location:9381047
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      cl02570
      Location:11501271
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    RNA

    1. XR_373946.5 RNA Sequence

    2. XR_373945.5 RNA Sequence

    3. XR_004940732.1 RNA Sequence

    4. XR_004940733.1 RNA Sequence