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    Pdss2 prenyl (solanesyl) diphosphate synthase, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 71365, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pdss2provided by MGI
    Official Full Name
    prenyl (solanesyl) diphosphate synthase, subunit 2provided by MGI
    Primary source
    MGI:MGI:1918615
    See related
    Ensembl:ENSMUSG00000038240 AllianceGenome:MGI:1918615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kd; Gm60; Plmp; mDLP1; 5430420P03Rik
    Summary
    Enables protein heterodimerization activity. Contributes to all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity. Involved in cerebellum development; isoprenoid biosynthetic process; and ubiquinone biosynthetic process. Acts upstream of or within regulation of body fluid levels. Located in mitochondrion. Part of heterotetrameric polyprenyl diphosphate synthase complex. Is expressed in several structures, including endocrine gland; genitourinary system; heart; nervous system; and stomach. Used to study coenzyme Q10 deficiency disease. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 3. Orthologous to human PDSS2 (decaprenyl diphosphate synthase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 2.3), adrenal adult (RPKM 2.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pdss2 in Genome Data Viewer
    Location:
    10 B2; 10 22.91 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43095396..43340878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43218248..43464882)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26500 Neighboring gene sine oculis binding protein Neighboring gene predicted gene, 47815 Neighboring gene RIKEN cDNA 9030612E09 gene Neighboring gene STARR-seq mESC enhancer starr_26502 Neighboring gene STARR-seq mESC enhancer starr_26503 Neighboring gene predicted gene, 40631 Neighboring gene STARR-positive B cell enhancer mm9_chr10:43098751-43099051 Neighboring gene ribosomal protein S19, pseudogene 11 Neighboring gene STARR-seq mESC enhancer starr_26505 Neighboring gene STARR-positive B cell enhancer mm9_chr10:43137256-43137557 Neighboring gene STARR-positive B cell enhancer ABC_E9031 Neighboring gene STARR-seq mESC enhancer starr_26511 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene BEN domain containing 3 Neighboring gene predicted gene, 47889

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    kidney disease
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in isoprenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in isoprenoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of body fluid levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquinone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotetrameric polyprenyl diphosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotetrameric polyprenyl diphosphate synthase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of polyprenyl diphosphate synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    all trans-polyprenyl-diphosphate synthase PDSS2
    Names
    all-trans-decaprenyl-diphosphate synthase subunit 2
    decaprenyl pyrophosphate synthase subunit 2
    decaprenyl pyrophosphate synthetase subunit 2
    decaprenyl-diphosphate synthase subunit 2
    prenyltransferase-like mitochondrial protein
    solanesyl-diphosphate synthase subunit 2
    NP_001161761.1
    NP_082048.2
    XP_006512915.1
    XP_006512916.1
    XP_006512917.1
    XP_036011908.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168289.1NP_001161761.1  all trans-polyprenyl-diphosphate synthase PDSS2 isoform 2

      See identical proteins and their annotated locations for NP_001161761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK140091, BY733519
      Consensus CDS
      CCDS48552.1
      UniProtKB/TrEMBL
      E0CYM9
      Related
      ENSMUSP00000124864.2, ENSMUST00000159139.8
      Conserved Domains (1) summary
      cl00210
      Location:65348
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    2. NM_027772.2NP_082048.2  all trans-polyprenyl-diphosphate synthase PDSS2 isoform 1

      See identical proteins and their annotated locations for NP_082048.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC152922, BC147693, BY733519
      Consensus CDS
      CCDS35891.1
      UniProtKB/Swiss-Prot
      B2RWA7, B2RWF3, Q33DR3, Q3USU6, Q9D3K7
      UniProtKB/TrEMBL
      E0CYM9
      Related
      ENSMUSP00000093393.5, ENSMUST00000095725.11
      Conserved Domains (1) summary
      cl00210
      Location:69401
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      43095396..43340878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512852.5XP_006512915.1  all trans-polyprenyl-diphosphate synthase PDSS2 isoform X1

      See identical proteins and their annotated locations for XP_006512915.1

      UniProtKB/TrEMBL
      E0CYM9
      Conserved Domains (1) summary
      cl00210
      Location:69390
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    2. XM_006512854.5XP_006512917.1  all trans-polyprenyl-diphosphate synthase PDSS2 isoform X3

      Conserved Domains (1) summary
      cl00210
      Location:69232
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    3. XM_036156015.1XP_036011908.1  all trans-polyprenyl-diphosphate synthase PDSS2 isoform X4

      Conserved Domains (1) summary
      cl00210
      Location:69241
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    4. XM_006512853.5XP_006512916.1  all trans-polyprenyl-diphosphate synthase PDSS2 isoform X2

      UniProtKB/TrEMBL
      E0CYM9
      Related
      ENSMUSP00000124046.2, ENSMUST00000160823.8
      Conserved Domains (1) summary
      cl00210
      Location:69320
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RNA

    1. XR_871439.4 RNA Sequence