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    TNNI1 troponin I1, slow skeletal type [ Homo sapiens (human) ]

    Gene ID: 7135, updated on 16-Apr-2024

    Summary

    Official Symbol
    TNNI1provided by HGNC
    Official Full Name
    troponin I1, slow skeletal typeprovided by HGNC
    Primary source
    HGNC:HGNC:11945
    See related
    Ensembl:ENSG00000159173 MIM:191042; AllianceGenome:HGNC:11945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNN1; SSTNI
    Summary
    Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in esophagus (RPKM 22.0), prostate (RPKM 20.7) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNNI1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (201403784..201421730, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200661585..200679520, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201372912..201390858, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene troponin T2, cardiac type Neighboring gene skeletal muscle cis-regulatory module in TNNT2 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201346239-201346776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201346777-201347314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201348651-201349414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201358357-201358857 Neighboring gene ladinin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201368148-201368810 Neighboring gene uncharacterized LOC101929343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2313 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2315 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201430707-201431289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201437987-201438701 Neighboring gene pleckstrin homology like domain family A member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp451O223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of striated muscle contraction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transition between fast and slow fiber IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of troponin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    troponin I, slow skeletal muscle
    Names
    troponin I type 1 (skeletal, slow)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016649.2 RefSeqGene

      Range
      5017..22963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003281.4NP_003272.3  troponin I, slow skeletal muscle

      See identical proteins and their annotated locations for NP_003272.3

      Status: REVIEWED

      Source sequence(s)
      AC096677, AL832006, BC012600
      Consensus CDS
      CCDS1411.1
      UniProtKB/Swiss-Prot
      A6NEH3, A8MSJ0, P19237, Q659A5, Q6FGS7, Q6FGW1, Q6ICU2, Q86T57, Q96DT9
      UniProtKB/TrEMBL
      B3KW26
      Related
      ENSP00000354488.4, ENST00000361379.9
      Conserved Domains (1) summary
      pfam00992
      Location:15146
      Troponin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      201403784..201421730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      200661585..200679520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)