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    Riok1 RIO kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 71340, updated on 5-Sep-2021

    Summary

    Official Symbol
    Riok1provided by MGI
    Official Full Name
    RIO kinase 1provided by MGI
    Primary source
    MGI:MGI:1918590
    See related
    Ensembl:ENSMUSG00000021428
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ad034; 3110046C13Rik; 5430416A05Rik
    Summary
    This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.2), CNS E14 (RPKM 8.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Riok1 in Genome Data Viewer
    Location:
    13; 13 A3.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38220965..38245409)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38036989..38061433)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (38129164..38153298)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene predicted gene, 52041 Neighboring gene signal sequence receptor, alpha Neighboring gene cancer antigen 1 Neighboring gene desmoplakin Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7300

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in maturation of SSU-rRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of preribosome, small subunit precursor ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase RIO1
    NP_077204.2
    XP_017171095.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024242.3NP_077204.2  serine/threonine-protein kinase RIO1

      See identical proteins and their annotated locations for NP_077204.2

      Status: REVIEWED

      Source sequence(s)
      AK152707, AV370421, CT010477
      Consensus CDS
      CCDS26461.1
      UniProtKB/Swiss-Prot
      Q922Q2
      Related
      ENSMUSP00000021866.9, ENSMUST00000021866.10
      Conserved Domains (2) summary
      COG1718
      Location:147386
      RIO1; Serine/threonine-protein kinase RIO1 [Signal transduction mechanisms]
      cd05147
      Location:181370
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38220965..38245409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315606.2XP_017171095.1  serine/threonine-protein kinase RIO1 isoform X1

      Conserved Domains (1) summary
      cd05147
      Location:15204
      RIO1_euk; Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase

    RNA

    1. XR_001780817.3 RNA Sequence

    2. XR_382077.4 RNA Sequence

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