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    TNFRSF1B TNF receptor superfamily member 1B [ Homo sapiens (human) ]

    Gene ID: 7133, updated on 19-Jul-2021

    Summary

    Official Symbol
    TNFRSF1Bprovided by HGNC
    Official Full Name
    TNF receptor superfamily member 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:11917
    See related
    Ensembl:ENSG00000028137 MIM:191191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 31.9), spleen (RPKM 25.2) and 23 other tissues See more
    Orthologs
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    Genomic context

    See TNFRSF1B in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (12166948..12209222)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12227048..12269277)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 8 Neighboring gene RNA, U6 small nuclear 777, pseudogene Neighboring gene ribosomal protein L23a pseudogene 89 Neighboring gene microRNA 7846 Neighboring gene uncharacterized LOC107984917 Neighboring gene microRNA 4632 Neighboring gene ribosomal protein L10 pseudogene 17 Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene NFE2L2 motif-containing MPRA enhancer 265

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV/tuberculosis coinfection upregulates TNFRSF1B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Apoptosis of CD8+ cells is mediated by the interaction between TNF-alpha bound to the membrane of macrophages (mbTNF) and a receptor on CD8+ T cells (TNF-receptor II, or TNFRII), which is upregulated by treatment with recombinant HIV-1 gp120 or SDF-1 PubMed
    env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b) PubMed
    Tat tat HIV-1 Tat downregulates the cell surface expression of the p80 form of the tumor necrosis factor receptor (TNFR2) PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tumor necrosis factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aortic valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glial cell-neuron signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of extracellular matrix constituent secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuroinflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neuron death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process involved in morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pulmonary valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of RNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of T cell cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of T cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokine production involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
     
    part_of tumor necrosis factor receptor superfamily complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 1B
    Names
    TNF-R2
    TNF-RII
    p75 TNF receptor
    p80 TNF-alpha receptor
    soluble TNFR1B variant 1
    tumor necrosis factor beta receptor
    tumor necrosis factor binding protein 2
    tumor necrosis factor receptor 2
    tumor necrosis factor receptor type II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029791.1 RefSeqGene

      Range
      4989..47218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001066.3NP_001057.1  tumor necrosis factor receptor superfamily member 1B precursor

      See identical proteins and their annotated locations for NP_001057.1

      Status: REVIEWED

      Source sequence(s)
      AL031276, AL357835
      Consensus CDS
      CCDS145.1
      UniProtKB/Swiss-Prot
      P20333
      Related
      ENSP00000365435.3, ENST00000376259.7
      Conserved Domains (1) summary
      cd10577
      Location:40201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      12166948..12209222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542060.2XP_011540362.1  tumor necrosis factor receptor superfamily member 1B isoform X2

      Conserved Domains (1) summary
      cd10577
      Location:40201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2
    2. XM_011542063.2XP_011540365.1  tumor necrosis factor receptor superfamily member 1B isoform X3

      Conserved Domains (1) summary
      cd10577
      Location:40201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2
    3. XM_017002214.1XP_016857703.1  tumor necrosis factor receptor superfamily member 1B isoform X4

    4. XM_017002215.1XP_016857704.1  tumor necrosis factor receptor superfamily member 1B isoform X5

      Related
      ENST00000492361.1
    5. XM_017002211.1XP_016857700.1  tumor necrosis factor receptor superfamily member 1B isoform X1

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