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    Dlg5 discs large MAGUK scaffold protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 71228, updated on 6-Nov-2018

    Summary

    Official Symbol
    Dlg5provided by MGI
    Official Full Name
    discs large MAGUK scaffold protein 5provided by MGI
    Primary source
    MGI:MGI:1918478
    See related
    Ensembl:ENSMUSG00000021782 Vega:OTTMUSG00000036719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T25557; mKIAA0583; 4933429D20Rik
    Expression
    Broad expression in limb E14.5 (RPKM 14.4), genital fat pad adult (RPKM 13.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See Dlg5 in Genome Data Viewer
    Location:
    14; 14 A3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (24133953..24246474, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (24953175..25065142, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31250 Neighboring gene microRNA 7210 Neighboring gene RIKEN cDNA E330034G19 gene Neighboring gene polymerase (RNA) III (DNA directed) polypeptide A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric collecting duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    polarized epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to adherens junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    zonula adherens assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    disks large homolog 5
    Names
    discs, large homolog 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163513.1NP_001156985.1  disks large homolog 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147598, AK147699, BC067046
      Consensus CDS
      CCDS49417.1
      UniProtKB/Swiss-Prot
      E9Q9R9
      UniProtKB/TrEMBL
      Q3UH41, Q6NXJ3
      Related
      ENSMUSP00000087879.4, OTTMUSP00000052282, ENSMUST00000090398.10, OTTMUST00000094102
      Conserved Domains (8) summary
      cd11860
      Location:16001662
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:17341910
      GuKc; Guanylate kinase homologues
      smart00228
      Location:13471429
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:722790
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04822
      Location:129213
      Takusan; Takusan
      pfam14197
      Location:545585
      Cep57_CLD_2; Centrosome localization domain of PPC89
      pfam16610
      Location:14271502
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl25732
      Location:141564
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_027726.1NP_082002.1  disks large homolog 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK147598, AK147699, BC067046
      Consensus CDS
      CCDS49416.1
      UniProtKB/Swiss-Prot
      E9Q9R9
      UniProtKB/TrEMBL
      E9Q9I2, Q3UH41, Q6NXJ3
      Related
      ENSMUSP00000073367.6, OTTMUSP00000052281, ENSMUST00000073687.12, OTTMUST00000094101
      Conserved Domains (10) summary
      cd11860
      Location:15771639
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:17111887
      GuKc; Guanylate kinase homologues
      smart00228
      Location:13241406
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG1340
      Location:272564
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:699767
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:17171886
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:107189
      Takusan; Takusan
      pfam16610
      Location:14041479
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:394578
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:287426
      FliJ; Flagellar FliJ protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      24133953..24246474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316200.1XP_017171689.1  disks large homolog 5 isoform X5

    2. XM_017316201.1XP_017171690.1  disks large homolog 5 isoform X6

    3. XM_006519560.2XP_006519623.1  disks large homolog 5 isoform X3

      Conserved Domains (11) summary
      cd11860
      Location:16051667
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:17391915
      GuKc; Guanylate kinase homologues
      smart00228
      Location:13521434
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:702776
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:295587
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:736795
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:17451914
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:130212
      Takusan; Takusan
      pfam16610
      Location:14321507
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:417601
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:310449
      FliJ; Flagellar FliJ protein
    4. XM_017316199.1XP_017171688.1  disks large homolog 5 isoform X4

    5. XM_017316198.1XP_017171687.1  disks large homolog 5 isoform X2

    6. XM_017316197.1XP_017171686.1  disks large homolog 5 isoform X1

    7. XM_017316202.1XP_017171691.1  disks large homolog 5 isoform X7

      Related
      ENSMUSP00000044852.6, OTTMUSP00000052280, ENSMUST00000042009.12, OTTMUST00000094100
    8. XM_017316203.1XP_017171692.1  disks large homolog 5 isoform X8

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