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    Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 [ Mus musculus (house mouse) ]

    Gene ID: 71207, updated on 16-Oct-2021

    Summary

    Official Symbol
    Nudt4provided by MGI
    Official Full Name
    nudix (nucleoside diphosphate linked moiety X)-type motif 4provided by MGI
    Primary source
    MGI:MGI:1918457
    See related
    Ensembl:ENSMUSG00000020029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIPP2; DIPP-2; HDCMB47P; DIPP2beta; DIPP2alpha; 4933436C10Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 90.4), colon adult (RPKM 66.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nudt4 in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (95382869..95400008, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (95547007..95564146, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (95009641..95026801, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46239 Neighboring gene ubiquitin-conjugating enzyme E2N Neighboring gene microRNA 3058 Neighboring gene predicted gene, 33336 Neighboring gene anaphase promoting complex C subunit 15, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diphosphoinositol-polyphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol diphosphate pentakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol diphosphate tetrakisphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables m7G(5')pppN diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 2
    Names
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
    nucleoside diphosphate-linked moiety X motif 4
    nudix motif 4
    NP_001345925.1
    NP_081998.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358996.1NP_001345925.1  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK017075, AK048062, BP753270, CJ208434
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    2. NM_027722.5NP_081998.3  diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2

      See identical proteins and their annotated locations for NP_081998.3

      Status: VALIDATED

      Source sequence(s)
      AK017075, AK048062, CJ208434
      Consensus CDS
      CCDS24138.1
      UniProtKB/Swiss-Prot
      Q8R2U6
      UniProtKB/TrEMBL
      Q4FJR0
      Related
      ENSMUSP00000020217.6, ENSMUST00000020217.7
      Conserved Domains (1) summary
      cd04666
      Location:18136
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      95382869..95400008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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