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    Arhgap19 Rho GTPase activating protein 19 [ Mus musculus (house mouse) ]

    Gene ID: 71085, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arhgap19provided by MGI
    Official Full Name
    Rho GTPase activating protein 19provided by MGI
    Primary source
    MGI:MGI:1918335
    See related
    Ensembl:ENSMUSG00000025154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI120128; AW546831; mFLJ00368; 4933411B03Rik
    Expression
    Broad expression in liver E14 (RPKM 16.1), testis adult (RPKM 15.6) and 17 other tissues See more
    Orthologs

    Genomic context

    See Arhgap19 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (41766588..41802084, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (41841078..41876574, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 1 Neighboring gene predicted gene, 34116 Neighboring gene predicted gene, 19424 Neighboring gene predicted gene, 41847 Neighboring gene frequently rearranged in advanced T cell lymphomas

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ00368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 19
    Names
    rho-type GTPase-activating protein 19

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163495.1NP_001156967.1  rho GTPase-activating protein 19 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC145557, BC086680
      Consensus CDS
      CCDS50435.1
      UniProtKB/Swiss-Prot
      Q8BRH3
      UniProtKB/TrEMBL
      E9Q4T1
      Related
      ENSMUSP00000129586.1, ENSMUST00000163265.7
      Conserved Domains (1) summary
      cd04392
      Location:113320
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
    2. NM_027667.3NP_081943.2  rho GTPase-activating protein 19 isoform 1

      See identical proteins and their annotated locations for NP_081943.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC145557, BC086680
      Consensus CDS
      CCDS37989.1
      UniProtKB/Swiss-Prot
      Q8BRH3
      Related
      ENSMUSP00000026150.8, ENSMUST00000026150.14
      Conserved Domains (1) summary
      cd04392
      Location:113320
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      41766588..41802084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247344.2XP_011245646.2  rho GTPase-activating protein 19 isoform X4

    2. XM_011247343.1XP_011245645.1  rho GTPase-activating protein 19 isoform X3

      Conserved Domains (1) summary
      cd04392
      Location:104311
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
    3. XM_011247341.1XP_011245643.1  rho GTPase-activating protein 19 isoform X1

      Conserved Domains (1) summary
      cd04392
      Location:104311
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
    4. XM_011247342.1XP_011245644.1  rho GTPase-activating protein 19 isoform X2

      Conserved Domains (1) summary
      cd04392
      Location:104311
      RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
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