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    SEC62 SEC62 homolog, preprotein translocation factor [ Homo sapiens (human) ]

    Gene ID: 7095, updated on 5-May-2024

    Summary

    Official Symbol
    SEC62provided by HGNC
    Official Full Name
    SEC62 homolog, preprotein translocation factorprovided by HGNC
    Primary source
    HGNC:HGNC:11846
    See related
    Ensembl:ENSG00000008952 MIM:602173; AllianceGenome:HGNC:11846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTP1; TP-1; Dtrp1; TLOC1
    Summary
    The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 46.4), brain (RPKM 36.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SEC62 in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (169966807..169998373)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172751051..172783070)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169684595..169716161)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:169653188-169653290 Neighboring gene family with sequence similarity 20 member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20790 Neighboring gene FHL1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20791 Neighboring gene NANOG hESC enhancer GRCh37_chr3:169686270-169686802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14877 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:169756663-169757162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20793 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:169763504-169764004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20794 Neighboring gene uncharacterized LOC124909455 Neighboring gene G protein-coupled receptor 160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169773599-169774098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169779520-169780041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169780042-169780562 Neighboring gene RNA, U4 small nuclear 38, pseudogene Neighboring gene KMT5A pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with SEC62 homolog (SEC62) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32803

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    translocation protein SEC62
    Names
    SEC62 preprotein translocation factor
    hTP-1
    membrane protein SEC62, S.cerevisiae, homolog of
    translocation protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003262.4NP_003253.1  translocation protein SEC62

      See identical proteins and their annotated locations for NP_003253.1

      Status: REVIEWED

      Source sequence(s)
      AC008040
      Consensus CDS
      CCDS3210.1
      UniProtKB/Swiss-Prot
      D3DNQ0, O00682, O00729, Q99442
      Related
      ENSP00000337688.4, ENST00000337002.9
      Conserved Domains (2) summary
      pfam05793
      Location:290369
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      pfam03839
      Location:170305
      Sec62; Translocation protein Sec62

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      169966807..169998373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448819.1XP_047304775.1  translocation protein SEC62 isoform X1

    2. XM_011513114.4XP_011511416.1  translocation protein SEC62 isoform X1

      See identical proteins and their annotated locations for XP_011511416.1

      Conserved Domains (2) summary
      pfam05793
      Location:252331
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      pfam03839
      Location:132267
      Sec62; Translocation protein Sec62

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      172751051..172783070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347706.1XP_054203681.1  translocation protein SEC62 isoform X1

    2. XM_054347705.1XP_054203680.1  translocation protein SEC62 isoform X1