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    Nol8 nucleolar protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 70930, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nol8provided by MGI
    Official Full Name
    nucleolar protein 8provided by MGI
    Primary source
    MGI:MGI:1918180
    See related
    Ensembl:ENSMUSG00000021392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D13Ertd548; 4921532D18Rik; 5730412B09Rik
    Expression
    Broad expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 5.9) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Nol8 in Genome Data Viewer
    Location:
    13 A5; 13 25.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49806554..49832492)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49653078..49679016)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49748719..49774384)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene osteomodulin Neighboring gene osteoglycin Neighboring gene predicted gene, 53786 Neighboring gene predicted gene, 25394 Neighboring gene isoleucine-tRNA synthetase Neighboring gene predicted gene, 23482

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in protein localization to nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271397.1NP_001258326.1  nucleolar protein 8

      See identical proteins and their annotated locations for NP_001258326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AK014994, AK147172, BC125575
      Consensus CDS
      CCDS36658.1
      UniProtKB/Swiss-Prot
      Q3UHX0
      UniProtKB/TrEMBL
      E9QKD1
      Related
      ENSMUSP00000152536.2, ENSMUST00000222197.2
      Conserved Domains (1) summary
      cd12226
      Location:27106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    RNA

    1. NR_073167.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK014994, AK147172, BC058699
    2. NR_073168.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC160978, AK014994, AK147172

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49806554..49832492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516956.3XP_006517019.2  nucleolar protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006517019.2

      UniProtKB/Swiss-Prot
      Q3UHX0
      Related
      ENSMUSP00000152878.2, ENSMUST00000223467.2
      Conserved Domains (1) summary
      cd12226
      Location:988
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
    2. XM_006516958.5XP_006517021.1  nucleolar protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006517021.1

      UniProtKB/TrEMBL
      E9QKD1
      Conserved Domains (1) summary
      cd12226
      Location:27106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins
    3. XM_006516957.1XP_006517020.1  nucleolar protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006517020.1

      UniProtKB/TrEMBL
      E9QKD1
      Related
      ENSMUSP00000021824.8, ENSMUST00000021824.8
      Conserved Domains (1) summary
      cd12226
      Location:27106
      RRM_NOL8; RNA recognition motif in nucleolar protein 8 (NOL8) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081350.1: Suppressed sequence

      Description
      NM_001081350.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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