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    TKT transketolase [ Homo sapiens (human) ]

    Gene ID: 7086, updated on 8-Jul-2021

    Summary

    Official Symbol
    TKTprovided by HGNC
    Official Full Name
    transketolaseprovided by HGNC
    Primary source
    HGNC:HGNC:11834
    See related
    Ensembl:ENSG00000163931 MIM:606781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TK; TKT1; SDDHD; HEL107; HEL-S-48
    Summary
    This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
    Expression
    Broad expression in bone marrow (RPKM 210.7), fat (RPKM 83.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TKT in Genome Data Viewer
    Location:
    3p21.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (53224712..53256052, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53258728..53290038, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene protein kinase C delta Neighboring gene Sharpr-MPRA regulatory region 8375 Neighboring gene uncharacterized LOC107986087 Neighboring gene CRISPRi-validated cis-regulatory element chr3.2458 Neighboring gene decapping mRNA 1A Neighboring gene small nucleolar RNA, C/D box 38C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of transketolase (TKT) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human transketolase (TKT) at amino acid residues178-179 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ34765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transketolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vesicle HDA PubMed 

    General protein information

    Preferred Names
    transketolase
    Names
    epididymis luminal protein 107
    epididymis secretory protein Li 48
    NP_001055.1
    NP_001128527.1
    NP_001244957.1
    XP_011532356.1
    XP_011532357.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027815.1 RefSeqGene

      Range
      5001..36408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001064.4NP_001055.1  transketolase isoform 1

      See identical proteins and their annotated locations for NP_001055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC097015, BC009970, BC024026, CA421169, DB503248, L12711
      Consensus CDS
      CCDS2871.1
      UniProtKB/Swiss-Prot
      P29401
      UniProtKB/TrEMBL
      V9HWD9
      Related
      ENSP00000417773.1, ENST00000462138.6
      Conserved Domains (1) summary
      PRK05899
      Location:8620
      PRK05899; transketolase; Reviewed
    2. NM_001135055.3NP_001128527.1  transketolase isoform 1

      See identical proteins and their annotated locations for NP_001128527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC097015, BE504944, BX647248, DB503248
      Consensus CDS
      CCDS2871.1
      UniProtKB/Swiss-Prot
      P29401
      UniProtKB/TrEMBL
      V9HWD9
      Related
      ENSP00000405455.2, ENST00000423525.6
      Conserved Domains (1) summary
      PRK05899
      Location:8620
      PRK05899; transketolase; Reviewed
    3. NM_001258028.2NP_001244957.1  transketolase isoform 2

      See identical proteins and their annotated locations for NP_001244957.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
      Source sequence(s)
      AC097015, AK293438, BC008615, CA421169
      Consensus CDS
      CCDS58834.1
      UniProtKB/Swiss-Prot
      P29401
      Related
      ENSP00000391481.1, ENST00000423516.5
      Conserved Domains (4) summary
      cd07033
      Location:327482
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:8628
      PRK05899; transketolase; Reviewed
      cd02012
      Location:20279
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:500620
      Transketolase_C; Transketolase, C-terminal domain

    RNA

    1. NR_047580.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC097015, AK301231, BC008615, CA421169

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      53224712..53256052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534054.1XP_011532356.1  transketolase isoform X1

      See identical proteins and their annotated locations for XP_011532356.1

      UniProtKB/Swiss-Prot
      P29401
      Conserved Domains (4) summary
      cd07033
      Location:327482
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:8628
      PRK05899; transketolase; Reviewed
      cd02012
      Location:20279
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:500620
      Transketolase_C; Transketolase, C-terminal domain
    2. XM_011534055.2XP_011532357.1  transketolase isoform X2

      See identical proteins and their annotated locations for XP_011532357.1

      UniProtKB/TrEMBL
      A0A0B4J1R6
      Related
      ENSP00000296289.7, ENST00000296289.10
      Conserved Domains (1) summary
      cl27366
      Location:1454
      TktA; Transketolase [Carbohydrate transport and metabolism]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001135056.1: Suppressed sequence

      Description
      NM_001135056.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with non-consensus splice sites.
    2. NR_047579.1: Suppressed sequence

      Description
      NR_047579.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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