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    Hmgxb4 HMG box domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 70823, updated on 7-Aug-2018

    Summary

    Official Symbol
    Hmgxb4provided by MGI
    Official Full Name
    HMG box domain containing 4provided by MGI
    Primary source
    MGI:MGI:1918073
    See related
    Ensembl:ENSMUSG00000034518 Vega:OTTMUSG00000017305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmgb2l1; AI316803; 4733401K04Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.5), limb E14.5 (RPKM 8.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hmgxb4 in Genome Data Viewer
    Location:
    8; 8 C1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (74993518..75031978)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (77517602..77555871)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene Luc7 homolog-like pseudogene Neighboring gene intestine specific homeobox Neighboring gene dpy-30 homolog pseudogene Neighboring gene target of myb1 trafficking protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • E430025G12

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    NURF complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    HMG domain-containing protein 4
    Names
    high mobility group box 2-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316753.1NP_001303682.1  HMG domain-containing protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL603864, BC048188, BC049800, CN456159
      UniProtKB/TrEMBL
      Q80Y32
      Conserved Domains (2) summary
      cd00084
      Location:291354
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:1116
      DUF4171; Domain of unknown function (DUF4171)
    2. NM_001316754.1NP_001303683.1  HMG domain-containing protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon in place of the first five exons compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC048188, BC049800, BY035054
      Consensus CDS
      CCDS85564.1
      UniProtKB/TrEMBL
      Q80Y32, Q8BTT5
      Related
      ENSMUSP00000105566.1, OTTMUSP00000018887, ENSMUST00000109940.1, OTTMUST00000042003
      Conserved Domains (1) summary
      cd00084
      Location:366
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    3. NM_178017.2NP_821136.1  HMG domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_821136.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC048188, BC049800, CN456159
      Consensus CDS
      CCDS22422.1
      UniProtKB/TrEMBL
      Q80Y32
      Related
      ENSMUSP00000045126.7, OTTMUSP00000018886, ENSMUST00000041759.13, OTTMUST00000042002
      Conserved Domains (2) summary
      cd00084
      Location:400463
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:107225
      DUF4171; Domain of unknown function (DUF4171)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      74993518..75031978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531362.3XP_006531425.2  HMG domain-containing protein 4 isoform X1

      Conserved Domains (2) summary
      cd00084
      Location:291354
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:1116
      DUF4171; Domain of unknown function (DUF4171)
    2. XM_006531364.1XP_006531427.1  HMG domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006531427.1

      Conserved Domains (2) summary
      cd00084
      Location:291354
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
      pfam13775
      Location:1116
      DUF4171; Domain of unknown function (DUF4171)

    RNA

    1. XR_001778467.1 RNA Sequence

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