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    Ankib1 ankyrin repeat and IBR domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70797, updated on 19-Mar-2019

    Summary

    Official Symbol
    Ankib1provided by MGI
    Official Full Name
    ankyrin repeat and IBR domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918047
    See related
    Ensembl:ENSMUSG00000040351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C80642; AW494740; mKIAA1386; 2310061P20Rik; 4631416I11Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 7.8), CNS E18 (RPKM 6.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ankib1 in Genome Data Viewer
    Location:
    5; 5 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (3689999..3803124, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (3690000..3803109, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108169020 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene transmembrane BAX inhibitor motif containing 7 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene mitochondrial transcription termination factor 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90780

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ankyrin repeat and IBR domain-containing protein 1
    NP_001003909.2
    NP_001276456.1
    NP_001276457.1
    NP_001276458.1
    XP_017176586.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003909.4NP_001003909.2  ankyrin repeat and IBR domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001003909.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC022236
      Consensus CDS
      CCDS51408.1
      UniProtKB/Swiss-Prot
      Q6ZPS6
      Related
      ENSMUSP00000040946.6, ENSMUST00000043551.10
      Conserved Domains (5) summary
      cd00204
      Location:47198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:403476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50176
      Ank_2; Ankyrin repeats (3 copies)
      pfam13639
      Location:334380
      zf-RING_2; Ring finger domain
      sd00045
      Location:4777
      ANK; ANK repeat [structural motif]
    2. NM_001289527.1NP_001276456.1  ankyrin repeat and IBR domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001276456.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC022236
      Conserved Domains (5) summary
      cd00204
      Location:47198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:403476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50176
      Ank_2; Ankyrin repeats (3 copies)
      pfam13639
      Location:334380
      zf-RING_2; Ring finger domain
      sd00045
      Location:4777
      ANK; ANK repeat [structural motif]
    3. NM_001289528.1NP_001276457.1  ankyrin repeat and IBR domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region and uses an alternate in-frame splice site in the 3' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC022236, BC079620, BC145510, CN526058
      UniProtKB/Swiss-Prot
      Q6ZPS6
      Conserved Domains (2) summary
      pfam01485
      Location:129202
      IBR; IBR domain, a half RING-finger domain
      pfam13639
      Location:60106
      zf-RING_2; Ring finger domain
    4. NM_001289529.1NP_001276458.1  ankyrin repeat and IBR domain-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR and contains an alternate exon in the 5' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK014523, BC079620, BC089031, CN526058
      UniProtKB/Swiss-Prot
      Q6ZPS6
      Conserved Domains (1) summary
      pfam01485
      Location:1162
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      3689999..3803124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321097.1XP_017176586.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd00204
      Location:47198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:403476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50176
      Ank_2; Ankyrin repeats (3 copies)
      pfam13639
      Location:334380
      zf-RING_2; Ring finger domain
      sd00045
      Location:4777
      ANK; ANK repeat [structural motif]
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