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    Ubr5 ubiquitin protein ligase E3 component n-recognin 5 [ Mus musculus (house mouse) ]

    Gene ID: 70790, updated on 12-Aug-2018

    Summary

    Official Symbol
    Ubr5provided by MGI
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 5provided by MGI
    Primary source
    MGI:MGI:1918040
    See related
    Ensembl:ENSMUSG00000037487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edd; Edd1
    Expression
    Ubiquitous expression in testis adult (RPKM 22.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ubr5 in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (37967328..38078854, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (37897083..38008608, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35019 Neighboring gene ribonucleotide reductase M2 B (TP53 inducible) Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 35081 Neighboring gene predicted gene, 35167

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA0896, D030042K14, 4432411E13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone H2A K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of histone H2A K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-17 secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    progesterone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase UBR5
    Names
    E3 ubiquitin-protein ligase, HECT domain-containing 1
    HECT-type E3 ubiquitin transferase UBR5
    extraembryonic development
    hyperplastic discs protein homolog
    NP_001074828.2
    NP_001106192.1
    XP_006520242.1
    XP_006520243.1
    XP_006520244.1
    XP_006520245.1
    XP_006520246.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081359.3NP_001074828.2  E3 ubiquitin-protein ligase UBR5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014485, AK162029, AY550908, CB527808, CJ063125, DV047629
      Consensus CDS
      CCDS49595.1
      UniProtKB/Swiss-Prot
      Q80TP3
      UniProtKB/TrEMBL
      E9Q2H1, Q3TSI5
      Related
      ENSMUSP00000154293.1, ENSMUST00000226414.1
      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23892452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:24672795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:25002798
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    2. NM_001112721.2NP_001106192.1  E3 ubiquitin-protein ligase UBR5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK014485, AK162029, AY550908, CB527808, CJ063125
      UniProtKB/Swiss-Prot
      Q80TP3
      UniProtKB/TrEMBL
      Q3TSI5
      Related
      ENSMUSP00000105965.3, ENSMUST00000110336.3
      Conserved Domains (5) summary
      smart00396
      Location:11711238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23832446
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:24612789
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:24942792
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      37967328..38078854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520182.3XP_006520245.1  E3 ubiquitin-protein ligase UBR5 isoform X4

      Conserved Domains (5) summary
      smart00396
      Location:11711238
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23852448
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:24632791
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:24962794
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    2. XM_006520181.3XP_006520244.1  E3 ubiquitin-protein ligase UBR5 isoform X3

      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23892452
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:24982793
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:24982796
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    3. XM_006520180.3XP_006520243.1  E3 ubiquitin-protein ligase UBR5 isoform X2

      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23912454
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:25002795
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:25002798
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    4. XM_006520179.3XP_006520242.1  E3 ubiquitin-protein ligase UBR5 isoform X1

      Conserved Domains (5) summary
      smart00396
      Location:11771244
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:23912454
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:24692797
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:25022800
      HECT; HECT-domain (ubiquitin-transferase)
      pfam11547
      Location:179226
      E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    5. XM_006520183.3XP_006520246.1  E3 ubiquitin-protein ligase UBR5 isoform X5

      Conserved Domains (4) summary
      smart00396
      Location:187254
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      smart00517
      Location:14011464
      PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
      smart00119
      Location:14791807
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00632
      Location:15121810
      HECT; HECT-domain (ubiquitin-transferase)

    RNA

    1. XR_001781565.1 RNA Sequence

    2. XR_383833.3 RNA Sequence

    3. XR_383834.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027553.1: Suppressed sequence

      Description
      NM_027553.1: This RefSeq was permanently suppressed because the CDS was partial.
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