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    Dclk2 doublecortin-like kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 70762, updated on 16-Oct-2021

    Summary

    Official Symbol
    Dclk2provided by MGI
    Official Full Name
    doublecortin-like kinase 2provided by MGI
    Primary source
    MGI:MGI:1918012
    See related
    Ensembl:ENSMUSG00000028078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CL2; CLICK2; Dcamkl2; AU044875; Click-II; 6330415M09Rik
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in whole brain E14.5 (RPKM 41.0), CNS E14 (RPKM 37.3) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dclk2 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (86693457..86828292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (86786150..86920952, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (86590073..86724803, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene LPS-responsive beige-like anchor Neighboring gene thymosin, beta 10 pseudogene Neighboring gene predicted gene, 52625 Neighboring gene predicted gene, 46810 Neighboring gene predicted gene, 23376 Neighboring gene CD1d2 antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase DCLK2
    Names
    caMK-like CREB regulatory kinase 2
    doublecortin and CaM kinase-like 2
    doublecortin-like and CAM kinase-like 2
    NP_001182425.1
    NP_001182426.1
    NP_001182427.1
    NP_001182428.1
    NP_001182429.1
    NP_001344389.1
    NP_081815.3
    XP_006502129.1
    XP_006502130.1
    XP_006502131.1
    XP_006502132.1
    XP_006502133.1
    XP_006502134.1
    XP_006502135.1
    XP_006502136.1
    XP_006502137.1
    XP_006502138.1
    XP_006502139.1
    XP_006502140.1
    XP_006502141.1
    XP_011238528.1
    XP_011238529.1
    XP_017175208.1
    XP_030108678.1
    XP_030108679.1
    XP_030108680.1
    XP_030108681.1
    XP_030108682.1
    XP_030108683.1
    XP_036019200.1
    XP_036019201.1
    XP_036019202.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195496.1NP_001182425.1  serine/threonine-protein kinase DCLK2 isoform 1

      See identical proteins and their annotated locations for NP_001182425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is an exon-5-containing transcript (PMIDs:15611072 and 18075264), and encodes the longest isoform (1).
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/Swiss-Prot
      Q6PGN3
      Conserved Domains (3) summary
      smart00220
      Location:408665
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:406664
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001195497.1NP_001182426.1  serine/threonine-protein kinase DCLK2 isoform 3

      See identical proteins and their annotated locations for NP_001182426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK049179, BC056921, BQ771344, BY361646
      Consensus CDS
      CCDS79936.1
      UniProtKB/Swiss-Prot
      Q6PGN3
      Related
      ENSMUSP00000142267.2, ENSMUST00000195561.6
      Conserved Domains (3) summary
      smart00220
      Location:392649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:390648
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001195498.1NP_001182427.1  serine/threonine-protein kinase DCLK2 isoform 4

      See identical proteins and their annotated locations for NP_001182427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264), and represents the longest transcript. It has an additional 3 nts at an alternate splice site and an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (4) has an extra aa in the middle region and has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/Swiss-Prot
      Q6PGN3
      Conserved Domains (3) summary
      smart00220
      Location:409666
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001195499.1NP_001182428.1  serine/threonine-protein kinase DCLK2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is an exon-5-containing and exon-17-containing transcript (PMIDs:15611072 and 18075264). It has an additional exon in the 3' region, which results in frame-shift, as compared to variant 1. The resulting isoform (5) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC102164, AC127237, AC132346
      UniProtKB/Swiss-Prot
      Q6PGN3
      Conserved Domains (3) summary
      smart00220
      Location:408665
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:406664
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001195500.2NP_001182429.1  serine/threonine-protein kinase DCLK2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an internal exon and several 3' exons, but has an alternate 3' segment, as compared to variant 1. The resulting isoform (6) lacks an internal segment and is C-terminal truncated, as compared to isoform 1.
      Source sequence(s)
      AK049126, BQ771344
      Consensus CDS
      CCDS79935.1
      UniProtKB/TrEMBL
      A0A0A6YX33
      Related
      ENSMUSP00000141816.2, ENSMUST00000194452.2
      Conserved Domains (3) summary
      smart00220
      Location:392590
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:390590
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001357460.1NP_001344389.1  serine/threonine-protein kinase DCLK2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC102164, AC127237, AC132346
      Conserved Domains (2) summary
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    7. NM_027539.5NP_081815.3  serine/threonine-protein kinase DCLK2 isoform 2

      See identical proteins and their annotated locations for NP_081815.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is an exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon and has an additional 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) is shorter; it lacks an internal segment but has a downstream extra aa, as compared to isoform 1.
      Source sequence(s)
      BC056921, BQ771344, BY361646
      Consensus CDS
      CCDS17448.1
      UniProtKB/Swiss-Prot
      Q6PGN3
      Related
      ENSMUSP00000029719.9, ENSMUST00000029719.14
      Conserved Domains (3) summary
      smart00220
      Location:393650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:391649
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      86693457..86828292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252823.2XP_030108683.1  serine/threonine-protein kinase DCLK2 isoform X23

      Related
      ENSMUSP00000141567.2, ENSMUST00000192773.6
      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390637
      PKc_like; Protein Kinases, catalytic domain
    2. XM_030252818.2XP_030108678.1  serine/threonine-protein kinase DCLK2 isoform X5

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390638
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030252821.2XP_030108681.1  serine/threonine-protein kinase DCLK2 isoform X18

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390648
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006502071.4XP_006502134.1  serine/threonine-protein kinase DCLK2 isoform X10

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390648
      PKc_like; Protein Kinases, catalytic domain
    5. XM_030252822.2XP_030108682.1  serine/threonine-protein kinase DCLK2 isoform X22

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391638
      PKc_like; Protein Kinases, catalytic domain
    6. XM_006502067.4XP_006502130.1  serine/threonine-protein kinase DCLK2 isoform X4

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391639
      PKc_like; Protein Kinases, catalytic domain
    7. XM_030252820.2XP_030108680.1  serine/threonine-protein kinase DCLK2 isoform X17

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391649
      PKc_like; Protein Kinases, catalytic domain
    8. XM_030252819.2XP_030108679.1  serine/threonine-protein kinase DCLK2 isoform X9

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:391649
      PKc_like; Protein Kinases, catalytic domain
    9. XM_036163308.1XP_036019201.1  serine/threonine-protein kinase DCLK2 isoform X3

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:406654
      PKc_like; Protein Kinases, catalytic domain
    10. XM_036163309.1XP_036019202.1  serine/threonine-protein kinase DCLK2 isoform X13

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:406664
      PKc_like; Protein Kinases, catalytic domain
    11. XM_011240226.3XP_011238528.1  serine/threonine-protein kinase DCLK2 isoform X11

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407607
      PKc_like; Protein Kinases, catalytic domain
    12. XM_017319719.3XP_017175208.1  serine/threonine-protein kinase DCLK2 isoform X24

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407607
      PKc_like; Protein Kinases, catalytic domain
    13. XM_011240227.3XP_011238529.1  serine/threonine-protein kinase DCLK2 isoform X25

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407607
      PKc_like; Protein Kinases, catalytic domain
    14. XM_006502076.4XP_006502139.1  serine/threonine-protein kinase DCLK2 isoform X19

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407654
      PKc_like; Protein Kinases, catalytic domain
    15. XM_006502070.4XP_006502133.1  serine/threonine-protein kinase DCLK2 isoform X8

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407659
      PKc_like; Protein Kinases, catalytic domain
    16. XM_006502078.4XP_006502141.1  serine/threonine-protein kinase DCLK2 isoform X21

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407654
      PKc_like; Protein Kinases, catalytic domain
    17. XM_006502066.4XP_006502129.1  serine/threonine-protein kinase DCLK2 isoform X2

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407655
      PKc_like; Protein Kinases, catalytic domain
    18. XM_006502074.4XP_006502137.1  serine/threonine-protein kinase DCLK2 isoform X15

      Related
      ENSMUSP00000141707.2, ENSMUST00000191752.6
      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407655
      PKc_like; Protein Kinases, catalytic domain
    19. XM_006502072.4XP_006502135.1  serine/threonine-protein kinase DCLK2 isoform X12

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    20. XM_006502068.4XP_006502131.1  serine/threonine-protein kinase DCLK2 isoform X6

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    21. XM_006502075.4XP_006502138.1  serine/threonine-protein kinase DCLK2 isoform X16

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    22. XM_006502069.4XP_006502132.1  serine/threonine-protein kinase DCLK2 isoform X7

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    23. XM_006502077.4XP_006502140.1  serine/threonine-protein kinase DCLK2 isoform X20

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407655
      PKc_like; Protein Kinases, catalytic domain
    24. XM_006502073.4XP_006502136.1  serine/threonine-protein kinase DCLK2 isoform X14

      Related
      ENSMUSP00000141866.2, ENSMUST00000193632.6
      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:407665
      PKc_like; Protein Kinases, catalytic domain
    25. XM_036163307.1XP_036019200.1  serine/threonine-protein kinase DCLK2 isoform X1

      Conserved Domains (3) summary
      cd17069
      Location:192275
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)
      cl21453
      Location:390648
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003954386.2 RNA Sequence

    2. XR_003954385.2 RNA Sequence

    3. XR_003954383.2 RNA Sequence

    4. XR_004941394.1 RNA Sequence

    5. XR_004941393.1 RNA Sequence

    6. XR_003954382.2 RNA Sequence

    7. XR_867231.4 RNA Sequence

    8. XR_003954387.2 RNA Sequence

    9. XR_867229.3 RNA Sequence

    10. XR_003954384.2 RNA Sequence

    11. XR_004941392.1 RNA Sequence

    12. XR_003954381.2 RNA Sequence

    13. XR_001783745.3 RNA Sequence

    14. XR_004941391.1 RNA Sequence

    15. XR_004941390.1 RNA Sequence

    16. XR_867230.4 RNA Sequence

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