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    Dcp2 decapping mRNA 2 [ Mus musculus (house mouse) ]

    Gene ID: 70640, updated on 13-Jul-2021

    Summary

    Official Symbol
    Dcp2provided by MGI
    Official Full Name
    decapping mRNA 2provided by MGI
    Primary source
    MGI:MGI:1917890
    See related
    Ensembl:ENSMUSG00000024472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AL118268; 2410015D23Rik; 5730537H01Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.4), cerebellum adult (RPKM 6.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Dcp2 in Genome Data Viewer
    Location:
    18; 18 B3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44513567..44558036)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44380500..44424969)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (44540154..44584623)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41717 Neighboring gene myotilin Neighboring gene mutated in colorectal cancers Neighboring gene predicted gene, 52347 Neighboring gene RIKEN cDNA A930012L18 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables m7G(5')pppN diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables m7G(5')pppN diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    m7GpppN-mRNA hydrolase
    Names
    DCP2 decapping enzyme homolog
    mRNA-decapping enzyme 2
    NP_081766.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027490.1NP_081766.1  m7GpppN-mRNA hydrolase

      See identical proteins and their annotated locations for NP_081766.1

      Status: VALIDATED

      Source sequence(s)
      AC147551, AK153105, AK153310
      Consensus CDS
      CCDS50275.1
      UniProtKB/Swiss-Prot
      Q9CYC6
      UniProtKB/TrEMBL
      Q3U671
      Related
      ENSMUSP00000025350.9, ENSMUST00000025350.10
      Conserved Domains (2) summary
      cd03672
      Location:97246
      Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
      pfam05026
      Location:1294
      DCP2; Dcp2, box A domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      44513567..44558036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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