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    Mipep mitochondrial intermediate peptidase [ Mus musculus (house mouse) ]

    Gene ID: 70478, updated on 4-Nov-2018

    Summary

    Official Symbol
    Mipepprovided by MGI
    Official Full Name
    mitochondrial intermediate peptidaseprovided by MGI
    Primary source
    MGI:MGI:1917728
    See related
    Ensembl:ENSMUSG00000021993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP; 5730405E07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 35.6), adrenal adult (RPKM 9.5) and 27 other tissues See more
    Orthologs

    Genomic context

    See Mipep in Genome Data Viewer
    Location:
    14; 14 D1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (60784562..60905481)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (61403403..61522450)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34997 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand Neighboring gene tumor necrosis factor receptor superfamily, member 19 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial intermediate peptidase
    NP_081712.2
    XP_006519571.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027436.3NP_081712.2  mitochondrial intermediate peptidase precursor

      See identical proteins and their annotated locations for NP_081712.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AI606287, AK017491, BE995975, CA460475
      Consensus CDS
      CCDS49517.1
      UniProtKB/Swiss-Prot
      A6H611
      Related
      ENSMUSP00000069840.7, ENSMUST00000063562.8
      Conserved Domains (2) summary
      cd06457
      Location:62695
      M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
      COG0339
      Location:71691
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_040642.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122477, AC151835

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      60784562..60905481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519508.2XP_006519571.1  mitochondrial intermediate peptidase isoform X1

      Related
      ENSMUSP00000153374.1, ENSMUST00000225506.1
      Conserved Domains (1) summary
      cd06457
      Location:62513
      M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
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