Format

Send to:

Choose Destination
    • Showing Current items.

    Mier2 MIER family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 70427, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mier2provided by MGI
    Official Full Name
    MIER family member 2provided by MGI
    Primary source
    MGI:MGI:1917677
    See related
    Ensembl:ENSMUSG00000042570 Vega:OTTMUSG00000035139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1193; 2700087H15Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 17.7), adrenal adult (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mier2 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (79540245..79558901, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79002990..79017836, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 83 Neighboring gene phospholipid phosphatase 2 Neighboring gene microRNA 6909 Neighboring gene testicular haploid expressed gene Neighboring gene C2 calcium-dependent domain containing 4C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II repressing transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mesoderm induction early response protein 2
    Names
    mesoderm induction early response 1, family member 2
    mi-er2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316699.1NP_001303628.1  mesoderm induction early response protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC067013, BY135743, CA317373
      Consensus CDS
      CCDS83723.1
      UniProtKB/Swiss-Prot
      Q3U3N0
      Related
      ENSMUSP00000127387.1, OTTMUSP00000048899, ENSMUST00000165028.7, OTTMUST00000089473
      Conserved Domains (3) summary
      smart00717
      Location:300346
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:301345
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:196246
      ELM2; ELM2 domain
    2. NM_027422.3NP_081698.2  mesoderm induction early response protein 2 isoform 2

      See identical proteins and their annotated locations for NP_081698.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
      Source sequence(s)
      BC067013, BY135743
      Consensus CDS
      CCDS48619.1
      UniProtKB/Swiss-Prot
      Q3U3N0
      Related
      ENSMUSP00000059864.8, OTTMUSP00000048900, ENSMUST00000062855.14, OTTMUST00000089474
      Conserved Domains (3) summary
      smart00717
      Location:298344
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:299343
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:194244
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      79540245..79558901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514083.2XP_006514146.1  mesoderm induction early response protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006514146.1

      Conserved Domains (3) summary
      smart00717
      Location:300346
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:301345
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:196246
      ELM2; ELM2 domain
    2. XM_006514086.1XP_006514149.1  mesoderm induction early response protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006514149.1

      Conserved Domains (3) summary
      smart00717
      Location:264310
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:265309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160210
      ELM2; ELM2 domain
    3. XM_006514082.1XP_006514145.1  mesoderm induction early response protein 2 isoform X2

      Conserved Domains (3) summary
      smart00717
      Location:313359
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:314358
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:209259
      ELM2; ELM2 domain
    4. XM_006514081.1XP_006514144.1  mesoderm induction early response protein 2 isoform X1

      Conserved Domains (3) summary
      smart00717
      Location:313359
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:314358
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:209259
      ELM2; ELM2 domain
    5. XM_017314086.1XP_017169575.1  mesoderm induction early response protein 2 isoform X4

      Conserved Domains (3) summary
      smart00717
      Location:264310
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:265309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160210
      ELM2; ELM2 domain
    6. XM_006514085.1XP_006514148.1  mesoderm induction early response protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006514148.1

      Conserved Domains (3) summary
      smart00717
      Location:264310
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:265309
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:160210
      ELM2; ELM2 domain
    Support Center