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    TGFB1 transforming growth factor beta 1 [ Homo sapiens (human) ]

    Gene ID: 7040, updated on 26-Jul-2021

    Summary

    Official Symbol
    TGFB1provided by HGNC
    Official Full Name
    transforming growth factor beta 1provided by HGNC
    Primary source
    HGNC:HGNC:11766
    See related
    Ensembl:ENSG00000105329 MIM:190180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in spleen (RPKM 38.0), bone marrow (RPKM 32.1) and 23 other tissues See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See TGFB1 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41330323..41353922, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41836228..41859827, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene B9 domain containing 2 Neighboring gene transmembrane protein 91 Neighboring gene exosome component 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cystic fibrosis Compare labs
    Diaphyseal dysplasia
    MedGen: C0011989 OMIM: 131300 GeneReviews: Camurati-Engelmann Disease
    Compare labs
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    GeneReviews: Not available
    Inflammatory bowel disease, immunodeficiency, and encephalopathy
    MedGen: C4748708 OMIM: 618213 GeneReviews: Not available
    Compare labs
    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is restricted by TGFB1 and SMAD2 in Langerhans cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Recombinant HIV-1 Env (gp120) induces high levels of TGFB1 mRNA expression in CD34+ hematopoietic progenitor cells PubMed
    env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
    env Inactivated HIV or gp120 increases HCV replication and enhances HCV-regulated transforming growth factor (TGF)-beta1 expression PubMed
    env HIV-1 gp120-induced apoptosis in human proximal renal tubular cells is significantly enhanced by p300, and Smad7 and an anti-TGF-beta antibody inhibit this effect of p300 PubMed
    env HIV-1 gp120 and p300 synergistically increase TGF-beta, ATF-2 and activating protein-1 (AP-1) expression leading to tubular cell apoptosis; in addition, HIV-1 gp120 treatment causes phosphorylation of Smad2 and downregulation of c-Jun PubMed
    env HIV-1 gp120-mediated suppression of CD34+ cell growth is entirely due to an upregulation of endogenous TGF-beta 1 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 induces TGF-beta production in human PBMC PubMed
    env HIV-1 gp160 and serum-free macrophage supernatant (MSP) enhance synthesis of type IV collagen by mesangial cells; anti-TGF-beta antibodies attenuate this gp160/MSP-induced collagen synthesis PubMed
    Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta PubMed
    tat HIV-1 Tat protein permits the survival and replication of a non-pathogenic trypanosomatid in macrophages through TGF-beta1 production PubMed
    tat HIV-1 Tat binds to GLI2 and GLI2 binds to the human TGFB1 promoter, suggesting a potential mechanism for TGFB1 induction in HIV-1 infection PubMed
    tat HIV-1 Tat and TGF-beta secretion enhance parasite entry in human macrophages by upregulating surface expression of CD91/LRP-1 PubMed
    tat TGF-beta inhibits/down-modulates HIV-1 Tat-induced IL-8 production PubMed
    tat HIV-1 Tat upregulation of TGF-beta 1 is likely involved in the regulation of MCP-1 transcription by Tat and the interactions of Tat with Smad-3 and Smad-4, two transcription factors whose activities are induced by the TGF-beta 1 pathway PubMed
    tat HIV-1 Tat upregulates TGF-beta 1 expression in a manner involving IL-6, an effect mediated by Tat amino acids 1-48 and potentially associated with immunosuppression, nephropathy, hematopoietic suppression and glomerulosclerosis PubMed
    Vpr vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
    Vpu vpu Antibodies against TGF-beta or a TGF-beta receptor inhibitor SB431452 reverse Vpu-mediated profibrogenic activation of LX2 cells, suggesting that TGF-beta mediates these effects PubMed
    vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
    capsid gag Treatment of monocyte-derived dendritic cells with TGF-beta1 significantly enhances their ability to capture HIV-1 particles measured by p24 levels in cells PubMed
    gag Transforming growth factor-beta1 is involved in the enhanced expression of HIV-1 by nicotine, as measured by p24 antigen levels in culture supernatants PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antigen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type I transforming growth factor beta receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables type I transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type II transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables type II transforming growth factor beta receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type II transforming growth factor beta receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables type II transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type III transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables type III transforming growth factor beta receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables type III transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in SMAD protein complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in aortic valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell junction organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in common-partner SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in connective tissue replacement involved in inflammatory response wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic liver development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extracellular matrix assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lymph node development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage derived foam cell differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in membrane protein intracellular domain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of biomineral tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extracellular matrix disassembly IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene silencing by miRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of hyaluronan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of production of miRNAs involved in gene silencing by miRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neural tube development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ossification involved in bone remodeling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in pathway-restricted SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphate-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of bone mineralization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix assembly IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-17 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of microglia differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of vascular permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood vessel remodeling IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of blood vessel remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of striated muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cholesterol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in salivary gland morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway involved in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in blood microparticle HDA PubMed 
    located_in cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    transforming growth factor beta-1 proprotein
    Names
    TGF-beta-1
    latency-associated peptide
    prepro-transforming growth factor beta-1
    transforming growth factor beta1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013364.1 RefSeqGene

      Range
      5005..28604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000660.7NP_000651.3  transforming growth factor beta-1 proprotein preproprotein

      See identical proteins and their annotated locations for NP_000651.3

      Status: REVIEWED

      Source sequence(s)
      AC011462, BC000125, BM692012, X02812
      Consensus CDS
      CCDS33031.1
      UniProtKB/Swiss-Prot
      P01137
      Related
      ENSP00000221930.4, ENST00000221930.6
      Conserved Domains (2) summary
      cd19384
      Location:292390
      TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
      pfam00688
      Location:30261
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41330323..41353922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527242.2XP_011525544.1  transforming growth factor beta-1 proprotein isoform X1

      See identical proteins and their annotated locations for XP_011525544.1

      Related
      ENSP00000504008.1, ENST00000600196.2
      Conserved Domains (2) summary
      cd19384
      Location:293391
      TGF_beta_TGFB1; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins
      pfam00688
      Location:30262
      TGFb_propeptide; TGF-beta propeptide
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