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    Ica1l islet cell autoantigen 1-like [ Mus musculus (house mouse) ]

    Gene ID: 70375, updated on 16-Oct-2021

    Summary

    Official Symbol
    Ica1lprovided by MGI
    Official Full Name
    islet cell autoantigen 1-likeprovided by MGI
    Primary source
    MGI:MGI:1917625
    See related
    Ensembl:ENSMUSG00000026018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Als2cr15; b2b3465Clo; 1700030B17Rik
    Expression
    Biased expression in testis adult (RPKM 8.3), CNS E18 (RPKM 6.5) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ica1l in Genome Data Viewer
    Location:
    1; 1 C2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60024955..60082646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59985796..60043481, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (60045912..60099931, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone morphogenetic protein receptor, type II (serine/threonine kinase) Neighboring gene family with sequence similarity 117, member B Neighboring gene arginyl-tRNA synthetase 2, mitochondrial pseudogene Neighboring gene WD repeat domain 12 Neighboring gene calcium response factor Neighboring gene predicted gene 15464

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1)  1 citation

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    islet cell autoantigen 1-like protein
    Names
    Ica69-related protein
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 15
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316694.1NP_001303623.1  islet cell autoantigen 1-like protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (a).
      Source sequence(s)
      AC125377, AK029991, BC079669
      Consensus CDS
      CCDS14987.1
      UniProtKB/Swiss-Prot
      Q3TY65
      Related
      ENSMUSP00000140520.2, ENSMUST00000191251.7
      Conserved Domains (2) summary
      pfam04629
      Location:254431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15242
      Arfaptin; Arfaptin-like domain
    2. NM_001316695.1NP_001303624.1  islet cell autoantigen 1-like protein isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has a single 3'-most exon in place of the last eight exons compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC125377, AK165131
      Related
      ENSMUST00000186970.2
      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_001357296.1NP_001344225.1  islet cell autoantigen 1-like protein isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same isoform (a).
      Source sequence(s)
      AC125377
      Consensus CDS
      CCDS14987.1
      Conserved Domains (2) summary
      pfam04629
      Location:254431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15242
      Arfaptin; Arfaptin-like domain
    4. NM_027407.4NP_081683.3  islet cell autoantigen 1-like protein isoform a

      See identical proteins and their annotated locations for NP_081683.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 4 encode the same isoform (a).
      Source sequence(s)
      AK029991, AK158859, BC079669
      Consensus CDS
      CCDS14987.1
      UniProtKB/Swiss-Prot
      Q3TY65
      Related
      ENSMUSP00000027172.7, ENSMUST00000027172.13
      Conserved Domains (2) summary
      pfam04629
      Location:254431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15242
      Arfaptin; Arfaptin-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60024955..60082646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153607.1XP_036009500.1  islet cell autoantigen 1-like protein isoform X7

      Conserved Domains (2) summary
      pfam04629
      Location:327365
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_036153596.1XP_036009489.1  islet cell autoantigen 1-like protein isoform X1

      Conserved Domains (2) summary
      pfam04629
      Location:276452
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_030242893.2XP_030098753.1  islet cell autoantigen 1-like protein isoform X2

      Conserved Domains (2) summary
      pfam04629
      Location:248425
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15236
      Arfaptin; Arfaptin-like domain
    4. XM_036153605.1XP_036009498.1  islet cell autoantigen 1-like protein isoform X5

      Conserved Domains (2) summary
      pfam04629
      Location:255414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_017312240.3XP_017167729.1  islet cell autoantigen 1-like protein isoform X5

      Conserved Domains (2) summary
      pfam04629
      Location:255414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_011238597.4XP_011236899.1  islet cell autoantigen 1-like protein isoform X4

      See identical proteins and their annotated locations for XP_011236899.1

      UniProtKB/Swiss-Prot
      Q3TY65
      Conserved Domains (2) summary
      pfam04629
      Location:254431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15242
      Arfaptin; Arfaptin-like domain
    7. XM_006496270.3XP_006496333.1  islet cell autoantigen 1-like protein isoform X4

      See identical proteins and their annotated locations for XP_006496333.1

      UniProtKB/Swiss-Prot
      Q3TY65
      Conserved Domains (2) summary
      pfam04629
      Location:254431
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15242
      Arfaptin; Arfaptin-like domain
    8. XM_017312238.2XP_017167727.1  islet cell autoantigen 1-like protein isoform X2

      Conserved Domains (2) summary
      pfam04629
      Location:248425
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15236
      Arfaptin; Arfaptin-like domain
    9. XM_006496272.3XP_006496335.1  islet cell autoantigen 1-like protein isoform X9

      See identical proteins and their annotated locations for XP_006496335.1

      Conserved Domains (2) summary
      pfam04629
      Location:150327
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:1144
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    10. XM_036153597.1XP_036009490.1  islet cell autoantigen 1-like protein isoform X3

      Conserved Domains (2) summary
      pfam04629
      Location:276435
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:67269
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    11. XM_030242896.2XP_030098756.1  islet cell autoantigen 1-like protein isoform X8

      Conserved Domains (2) summary
      pfam04629
      Location:310344
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    12. XM_030242895.1XP_030098755.1  islet cell autoantigen 1-like protein isoform X6

      Conserved Domains (2) summary
      pfam04629
      Location:248408
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      pfam06456
      Location:15236
      Arfaptin; Arfaptin-like domain
    13. XM_030242894.2XP_030098754.1  islet cell autoantigen 1-like protein isoform X5

      Related
      ENSMUSP00000141103.2, ENSMUST00000189776.2
      Conserved Domains (2) summary
      pfam04629
      Location:255414
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    14. XM_030242898.2XP_030098758.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    15. XM_017312257.3XP_017167746.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    16. XM_030242897.2XP_030098757.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    17. XM_030242900.1XP_030098760.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    18. XM_017312256.2XP_017167745.1  islet cell autoantigen 1-like protein isoform X10

      Conserved Domains (1) summary
      cl12013
      Location:1584
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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