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    Bag5 BCL2-associated athanogene 5 [ Mus musculus (house mouse) ]

    Gene ID: 70369, updated on 23-Jun-2021

    Summary

    Official Symbol
    Bag5provided by MGI
    Official Full Name
    BCL2-associated athanogene 5provided by MGI
    Primary source
    MGI:MGI:1917619
    See related
    Ensembl:ENSMUSG00000049792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bag-5; 1600025G07Rik; 4930405J06Rik
    Expression
    Biased expression in testis adult (RPKM 180.4), CNS E11.5 (RPKM 14.4) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bag5 in Genome Data Viewer
    Location:
    12; 12 F1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111675922..111679690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111709488..111713256, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (112947699..112951467, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene kinesin light chain 1 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inclusion body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inclusion body assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 5
    Names
    BAG-family molecular chaperone regulator-5 (BAG-5)
    bcl-2-associated athanogene 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324480.1NP_001311409.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AC152065, AK160246, BC055762, CJ046703
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q8CI32
      Related
      ENSMUSP00000125183.2, ENSMUST00000160576.2
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins
    2. NM_001324481.1NP_001311410.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AK160246, BC055762, CJ046703
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q8CI32
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins
    3. NM_001324482.1NP_001311411.1  BAG family molecular chaperone regulator 5

      Status: VALIDATED

      Source sequence(s)
      AC152065, AK160246, BC055762, CJ047026
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q8CI32
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins
    4. NM_027404.2NP_081680.1  BAG family molecular chaperone regulator 5

      See identical proteins and their annotated locations for NP_081680.1

      Status: VALIDATED

      Source sequence(s)
      AC152065, BC055762, CX243791
      Consensus CDS
      CCDS26185.1
      UniProtKB/Swiss-Prot
      Q8CI32
      Related
      ENSMUSP00000051049.7, ENSMUST00000054636.7
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111675922..111679690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516217.5XP_006516280.1  BAG family molecular chaperone regulator 5 isoform X1

      See identical proteins and their annotated locations for XP_006516280.1

      UniProtKB/Swiss-Prot
      Q8CI32
      Conserved Domains (1) summary
      smart00264
      Location:986
      BAG; BAG domains, present in regulator of Hsp70 proteins
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