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    Ppp4r1 protein phosphatase 4, regulatory subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 70351, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ppp4r1provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 1provided by MGI
    Primary source
    MGI:MGI:1917601
    See related
    Ensembl:ENSMUSG00000061950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp4r1; 3110001J10Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 40.7), CNS E14 (RPKM 12.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ppp4r1 in Genome Data Viewer
    Location:
    17; 17 E1.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (65782378..65841926)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (66132695..66191266)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene RAB31, member RAS oncogene family Neighboring gene ralA binding protein 1 Neighboring gene predicted gene, 35550

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Clone Names

    • MGC31567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    protein phosphatase 4 complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114131.1NP_001107603.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, CX568699
      Consensus CDS
      CCDS50167.1
      UniProtKB/Swiss-Prot
      Q8K2V1
      UniProtKB/TrEMBL
      E9PX53, Q3TLM9
      Related
      ENSMUSP00000124690.1, ENSMUST00000160664.7
      Conserved Domains (2) summary
      pfam15017
      Location:419475
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:116140
      HEAT; HEAT repeat [structural motif]
    2. NM_146081.2NP_666193.2  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC139751, AK133969, AK166418, AV275830, BC026489, BI135060, BY163631, CX568699
      Consensus CDS
      CCDS28941.2
      UniProtKB/Swiss-Prot
      Q8K2V1
      UniProtKB/TrEMBL
      E9QPR5, Q3TLM9
      Related
      ENSMUSP00000072848.4, ENSMUST00000073104.10
      Conserved Domains (2) summary
      pfam15017
      Location:436492
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:133157
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_104465.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC139751, AK133969, AK167713, BI135060
      Related
      ENSMUST00000162109.7
    2. NR_152099.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139751, BI135060, CT025659

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      65782378..65841926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524890.3XP_006524953.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524953.1

      Conserved Domains (2) summary
      pfam15017
      Location:393449
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:90114
      HEAT; HEAT repeat [structural motif]
    2. XM_006524889.3XP_006524952.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524952.1

      Conserved Domains (2) summary
      pfam15017
      Location:393449
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:90114
      HEAT; HEAT repeat [structural motif]
    3. XM_006524888.3XP_006524951.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524951.1

      Conserved Domains (2) summary
      pfam15017
      Location:393449
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:90114
      HEAT; HEAT repeat [structural motif]
    4. XM_006524894.3XP_006524957.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006524957.1

      UniProtKB/Swiss-Prot
      Q8K2V1
      Conserved Domains (2) summary
      pfam15017
      Location:87126
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:316344
      HEAT; HEAT repeat [structural motif]
    5. XM_006524891.3XP_006524954.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524954.1

      Conserved Domains (2) summary
      pfam15017
      Location:393449
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:90114
      HEAT; HEAT repeat [structural motif]
    6. XM_006524892.3XP_006524955.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006524955.1

      Conserved Domains (2) summary
      pfam15017
      Location:393449
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:90114
      HEAT; HEAT repeat [structural motif]
    7. XM_006524895.3XP_006524958.1  serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006524958.1

      UniProtKB/Swiss-Prot
      Q8K2V1
      Conserved Domains (2) summary
      pfam15017
      Location:87126
      AF1Q; Drug resistance and apoptosis regulator
      sd00044
      Location:316344
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001782110.1 RNA Sequence

    2. XR_001782111.1 RNA Sequence

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