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    Hdac8 histone deacetylase 8 [ Mus musculus (house mouse) ]

    Gene ID: 70315, updated on 8-Dec-2018

    Summary

    Official Symbol
    Hdac8provided by MGI
    Official Full Name
    histone deacetylase 8provided by MGI
    Primary source
    MGI:MGI:1917565
    See related
    Ensembl:ENSMUSG00000067567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610007D20Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hdac8 in Genome Data Viewer
    Location:
    X; X D
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (102284638..102507710, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (99479979..99700487, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 Neighboring gene predicted gene 14858 Neighboring gene predicted gene, 32262 Neighboring gene phosphorylase kinase alpha 1 Neighboring gene transcriptional adaptor 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    histone H3 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cohesin loading ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone deacetylase 8
    Names
    HD8
    NP_001300671.1
    NP_081658.1
    XP_006528338.1
    XP_006528339.1
    XP_011245972.1
    XP_011245973.1
    XP_011245975.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313742.1NP_001300671.1  histone deacetylase 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK034511, AK131998
      UniProtKB/Swiss-Prot
      Q8VH37
      Conserved Domains (1) summary
      cl17011
      Location:16246
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. NM_027382.4NP_081658.1  histone deacetylase 8 isoform 1

      See identical proteins and their annotated locations for NP_081658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK131998, AL954850
      Consensus CDS
      CCDS41084.1
      UniProtKB/Swiss-Prot
      Q8VH37
      Related
      ENSMUSP00000085226.4, ENSMUST00000087916.10
      Conserved Domains (1) summary
      cd10000
      Location:16377
      HDAC8; Histone deacetylase 8 (HDAC8)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      102284638..102507710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528275.3XP_006528338.1  histone deacetylase 8 isoform X1

      Conserved Domains (1) summary
      cd10000
      Location:16370
      HDAC8; Histone deacetylase 8 (HDAC8)
    2. XM_006528276.3XP_006528339.1  histone deacetylase 8 isoform X3

      Conserved Domains (1) summary
      cd10000
      Location:16335
      HDAC8; Histone deacetylase 8 (HDAC8)
    3. XM_011247670.2XP_011245972.1  histone deacetylase 8 isoform X2

      Conserved Domains (1) summary
      cd10000
      Location:16337
      HDAC8; Histone deacetylase 8 (HDAC8)
    4. XM_011247671.2XP_011245973.1  histone deacetylase 8 isoform X4

      Conserved Domains (1) summary
      cd10000
      Location:16335
      HDAC8; Histone deacetylase 8 (HDAC8)
    5. XM_011247673.2XP_011245975.1  histone deacetylase 8 isoform X5

      Conserved Domains (1) summary
      cl17011
      Location:16153
      Arginase_HDAC; Arginase-like and histone-like hydrolases
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