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    Rnf126 ring finger protein 126 [ Mus musculus (house mouse) ]

    Gene ID: 70294, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf126provided by MGI
    Official Full Name
    ring finger protein 126provided by MGI
    Primary source
    MGI:MGI:1917544
    See related
    Ensembl:ENSMUSG00000035890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610010O19Rik
    Expression
    Broad expression in testis adult (RPKM 392.3), ovary adult (RPKM 96.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Rnf126 in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79594349..79607282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79758515..79771448, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79221260..79229686, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) mitochondrial (DNA directed) Neighboring gene fibroblast growth factor 22 Neighboring gene follistatin-like 3 Neighboring gene protease, serine 57 Neighboring gene predicted gene, 40713 Neighboring gene paralemmin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF126
    NP_653111.1
    XP_006514138.1
    XP_017169570.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144528.3NP_653111.1  E3 ubiquitin-protein ligase RNF126

      See identical proteins and their annotated locations for NP_653111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes a functional protein.
      Source sequence(s)
      AC151828
      Consensus CDS
      CCDS23989.1
      UniProtKB/Swiss-Prot
      Q91YL2
      UniProtKB/TrEMBL
      Q3U3G2
      Related
      ENSMUSP00000039486.9, ENSMUST00000047203.9
      Conserved Domains (2) summary
      cd16801
      Location:230273
      RING-H2_RNF126; RING finger, H2 subclass, found in RING finger protein 126 (RNF126) and similar proteins
      pfam14369
      Location:1040
      zinc_ribbon_9; zinc-ribbon

    RNA

    1. NR_027505.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it does not have an in-frame coding region, compared to variant 1.
      Source sequence(s)
      AC151828, AK042319, BU147682
      Related
      ENSMUST00000218770.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79594349..79607282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514075.4XP_006514138.1  E3 ubiquitin-protein ligase RNF126 isoform X2

      Conserved Domains (1) summary
      pfam14369
      Location:1040
      zinc_ribbon_9; zinc-ribbon
    2. XM_017314081.2XP_017169570.1  E3 ubiquitin-protein ligase RNF126 isoform X1

      Conserved Domains (1) summary
      pfam14369
      Location:1040
      zinc_ribbon_9; zinc-ribbon

    RNA

    1. XR_001779593.3 RNA Sequence

    2. XR_004936269.1 RNA Sequence

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