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    TFDP2 transcription factor Dp-2 [ Homo sapiens (human) ]

    Gene ID: 7029, updated on 17-Sep-2024

    Summary

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    Official Symbol
    TFDP2provided by HGNC
    Official Full Name
    transcription factor Dp-2provided by HGNC
    Primary source
    HGNC:HGNC:11751
    See related
    Ensembl:ENSG00000114126 MIM:602160; AllianceGenome:HGNC:11751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP2
    Summary
    The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141944428..142149544, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144691750..144896866, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141663270..141868386, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141623266-141623766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141623767-141624267 Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene RNA, U6 small nuclear 509, pseudogene Neighboring gene uncharacterized LOC124909442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141656589-141657435 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:141719615-141719808 Neighboring gene Sharpr-MPRA regulatory region 4576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14783 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141747218-141747719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20640 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:141868031-141868531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14787 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141883131-141883866 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14789 Neighboring gene glycerol kinase 5 Neighboring gene NANOG hESC enhancer GRCh37_chr3:141961954-141962455 Neighboring gene Sharpr-MPRA regulatory region 12219 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene RNA, U6 small nuclear 1294, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells. Stinson SE, et al. J Allergy Clin Immunol, 2015 Feb. PMID 25312757, Free PMC Article
    2. Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP. Park KK, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927774
    3. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Zheng N, et al. Genes Dev, 1999 Mar 15. PMID 10090723, Free PMC Article
    4. Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor. Loiseau L, et al. Gene Expr, 1997. PMID 9368098, Free PMC Article
    5. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Zhang Y, et al. Oncogene, 1995 Jun 1. PMID 7784053

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
      Title: Identification of four new susceptibility loci for testicular germ cell tumour.
    2. DP2 is expressed by the bronchial epithelium, and its activation drives epithelial differentiation, suggesting that in addition to its well-characterized role in inflammatory cell migration, DP2 might contribute to airway remodeling in asthmatic patients.
      Title: D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells.
    3. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: New loci associated with kidney function and chronic kidney disease.
    4. This study demonstrates translation from an internal methionine.
      Title: DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    New loci associated with kidney function and chronic kidney disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transcription factor Dp-2 (E2F dimerization partner 2; TFDP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39131, DKFZp313O196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Dp-2
    Names
    transcription factor Dp-2 (E2F dimerization partner 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178138.2 → NP_001171609.1  transcription factor Dp-2 isoform 1

      See identical proteins and their annotated locations for NP_001171609.1

      Status: REVIEWED

      Source sequence(s)
      AC112504, BC013993, BC040991, DA321332
      Consensus CDS
      CCDS43159.1
      UniProtKB/Swiss-Prot
      Q14188
      Related
      ENSP00000418590.1, ENST00000467072.5
      Conserved Domains (3) summary
      cd14458
      Location:153 → 199
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 148
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:155 → 293
      DP; Transcription factor DP

    2. NM_001178139.2 → NP_001171610.1  transcription factor Dp-2 isoform 2

      See identical proteins and their annotated locations for NP_001171610.1

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648, AC133435, AK314786, BC013993, BC040991, DA321332
      Consensus CDS
      CCDS54650.1
      UniProtKB/Swiss-Prot
      B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28
      Related
      ENSP00000420616.1, ENST00000489671.6
      Conserved Domains (3) summary
      cd14458
      Location:213 → 259
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 208
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:215 → 353
      DP; Transcription factor DP

    3. NM_001178140.2 → NP_001171611.1  transcription factor Dp-2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648
      Consensus CDS
      CCDS54648.1
      UniProtKB/Swiss-Prot
      Q14188
      Related
      ENSP00000439782.2, ENST00000499676.5
      Conserved Domains (3) summary
      cd14458
      Location:185 → 231
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:100 → 180
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:187 → 325
      DP; Transcription factor DP

    4. NM_001178141.2 → NP_001171612.1  transcription factor Dp-2 isoform 4

      See identical proteins and their annotated locations for NP_001171612.1

      Status: REVIEWED

      Source sequence(s)
      AC112504, AK303634, BC040991, DC319314
      Consensus CDS
      CCDS54649.1
      UniProtKB/Swiss-Prot
      Q14188
      Related
      ENSP00000419036.1, ENST00000495310.5
      Conserved Domains (2) summary
      pfam02319
      Location:32 → 111
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:118 → 256
      DP; Transcription factor DP

    5. NM_001178142.2 → NP_001171613.1  transcription factor Dp-2 isoform 5

      See identical proteins and their annotated locations for NP_001171613.1

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648, AK303181, BC040991
      Consensus CDS
      CCDS54647.1
      UniProtKB/Swiss-Prot
      Q14188
      Related
      ENSP00000418971.1, ENST00000477292.5
      Conserved Domains (3) summary
      cd14458
      Location:77 → 123
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 72
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:79 → 217
      DP; Transcription factor DP

    6. NM_001375756.1 → NP_001362685.1  transcription factor Dp-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648, AC133435
      Consensus CDS
      CCDS93401.1
      Related
      ENSP00000417585.1, ENST00000479040.5
      Conserved Domains (3) summary
      cd14458
      Location:152 → 198
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 147
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:154 → 292
      DP; Transcription factor DP

    7. NM_001375773.1 → NP_001362702.1  transcription factor Dp-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC108679, AC112504, AC128648, AC133435
      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 354
      DP; Transcription factor DP

    8. NM_001375774.1 → NP_001362703.1  transcription factor Dp-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648, AC133435
      Conserved Domains (3) summary
      cd14458
      Location:196 → 242
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:111 → 191
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:198 → 336
      DP; Transcription factor DP

    9. NM_001375775.1 → NP_001362704.1  transcription factor Dp-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC108679, AC112504, AC128648, AC133435
      Conserved Domains (3) summary
      cd14458
      Location:191 → 237
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:107 → 186
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:193 → 331
      DP; Transcription factor DP

    10. NM_001375776.1 → NP_001362705.1  transcription factor Dp-2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC108679, AC112504, AC128648, AC133435
      Consensus CDS
      CCDS43159.1
      Conserved Domains (3) summary
      cd14458
      Location:153 → 199
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 148
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:155 → 293
      DP; Transcription factor DP

    11. NM_001375778.1 → NP_001362707.1  transcription factor Dp-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC108679, AC112504, AC128648, AC133435
      Consensus CDS
      CCDS93401.1
      Conserved Domains (3) summary
      cd14458
      Location:152 → 198
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 147
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:154 → 292
      DP; Transcription factor DP

    12. NM_001375779.1 → NP_001362708.1  transcription factor Dp-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC112504, AC128648, AC133435
      Conserved Domains (3) summary
      cd14458
      Location:100 → 146
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:16 → 95
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:102 → 240
      DP; Transcription factor DP

    13. NM_001375780.1 → NP_001362709.1  transcription factor Dp-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC108679, AC112504, AC128648, AC133435
      Conserved Domains (3) summary
      cd14458
      Location:100 → 146
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:16 → 95
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:102 → 240
      DP; Transcription factor DP

    14. NM_006286.5 → NP_006277.1  transcription factor Dp-2 isoform 1

      See identical proteins and their annotated locations for NP_006277.1

      Status: REVIEWED

      Description
      Transcript Variant:).
      Source sequence(s)
      AC112504, BC040991, DC319314, U18422
      Consensus CDS
      CCDS43159.1
      UniProtKB/Swiss-Prot
      Q14188
      Related
      ENSP00000420599.1, ENST00000486111.5
      Conserved Domains (3) summary
      cd14458
      Location:153 → 199
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:68 → 148
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:155 → 293
      DP; Transcription factor DP

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      141944428..142149544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007100.3 → XP_016862589.1  transcription factor Dp-2 isoform X9

    2. XM_011513107.3 → XP_011511409.1  transcription factor Dp-2 isoform X8

      Conserved Domains (3) summary
      cd14458
      Location:214 → 260
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 209
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:216 → 352
      DP; Transcription factor DP

    3. XM_047448783.1 → XP_047304739.1  transcription factor Dp-2 isoform X9

    4. XM_017007091.2 → XP_016862580.1  transcription factor Dp-2 isoform X2

      UniProtKB/Swiss-Prot
      B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28
      Conserved Domains (3) summary
      cd14458
      Location:213 → 259
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:129 → 208
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:215 → 353
      DP; Transcription factor DP

    5. XM_047448775.1 → XP_047304731.1  transcription factor Dp-2 isoform X1

    6. XM_047448779.1 → XP_047304735.1  transcription factor Dp-2 isoform X4

    7. XM_047448785.1 → XP_047304741.1  transcription factor Dp-2 isoform X11

    8. XM_047448784.1 → XP_047304740.1  transcription factor Dp-2 isoform X10

    9. XM_047448782.1 → XP_047304738.1  transcription factor Dp-2 isoform X7

    10. XM_047448781.1 → XP_047304737.1  transcription factor Dp-2 isoform X6

    11. XM_047448780.1 → XP_047304736.1  transcription factor Dp-2 isoform X5

    12. XM_047448777.1 → XP_047304733.1  transcription factor Dp-2 isoform X4

    13. XM_047448776.1 → XP_047304732.1  transcription factor Dp-2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      144691750..144896866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347651.1 → XP_054203626.1  transcription factor Dp-2 isoform X2

      UniProtKB/Swiss-Prot
      B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28

    2. XM_054347656.1 → XP_054203631.1  transcription factor Dp-2 isoform X9

    3. XM_054347655.1 → XP_054203630.1  transcription factor Dp-2 isoform X8

    4. XM_054347657.1 → XP_054203632.1  transcription factor Dp-2 isoform X9

    5. XM_054347648.1 → XP_054203623.1  transcription factor Dp-2 isoform X1

    6. XM_054347649.1 → XP_054203624.1  transcription factor Dp-2 isoform X1

    7. XM_054347650.1 → XP_054203625.1  transcription factor Dp-2 isoform X2

      UniProtKB/Swiss-Prot
      B7Z8C8, B7Z8L5, D3DNG1, E9PFC3, F8WAI2, Q13331, Q14187, Q14188, Q6R754, Q8WU88, Q9UG28

    8. XM_054347653.1 → XP_054203628.1  transcription factor Dp-2 isoform X4

    9. XM_054347658.1 → XP_054203633.1  transcription factor Dp-2 isoform X10

    10. XM_054347654.1 → XP_054203629.1  transcription factor Dp-2 isoform X5

    11. XM_054347659.1 → XP_054203634.1  transcription factor Dp-2 isoform X11

    12. XM_054347652.1 → XP_054203627.1  transcription factor Dp-2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14188.2 GenPept UniProtKB/Swiss-Prot:Q14188

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