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    Dazap1 DAZ associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70248, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dazap1provided by MGI
    Official Full Name
    DAZ associated protein 1provided by MGI
    Primary source
    MGI:MGI:1917498
    See related
    Ensembl:ENSMUSG00000069565 AllianceGenome:MGI:1917498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPrrp; 2410042M16Rik
    Summary
    Enables RNA stem-loop binding activity. Acts upstream of or within several processes, including fibroblast proliferation; maternal placenta development; and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human DAZAP1 (DAZ associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 42.4), duodenum adult (RPKM 40.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dazap1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80097168..80124242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80261362..80288408)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene STARR-positive B cell enhancer ABC_E5153 Neighboring gene STARR-positive B cell enhancer ABC_E10627 Neighboring gene guanidinoacetate methyltransferase Neighboring gene microRNA 6911 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene ribosomal protein S15 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(G) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(G) binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DAZ-associated protein 1
    Names
    deleted in azoospermia-associated protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122604.2NP_001116076.1  DAZ-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001116076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) has an additional aa in the N-terminal region, compared to isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS48626.1
      UniProtKB/Swiss-Prot
      Q9JII5
      UniProtKB/TrEMBL
      Q3U878
      Related
      ENSMUSP00000089958.6, ENSMUST00000092305.6
      Conserved Domains (2) summary
      cd12327
      Location:111190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:1192
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    2. NM_001122605.2NP_001116077.1  DAZ-associated protein 1 isoform c

      See identical proteins and their annotated locations for NP_001116077.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (c) has an additional aa in the C-terminal region, compared to isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS48627.1
      UniProtKB/TrEMBL
      Q3U878, Q3UGB5
      Related
      ENSMUSP00000101000.4, ENSMUST00000105361.10
      Conserved Domains (2) summary
      cd12327
      Location:110189
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:1192
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    3. NM_001378995.1NP_001365924.1  DAZ-associated protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (d).
      Source sequence(s)
      AC140229
      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:111190
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:1192
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    4. NM_133188.3NP_573451.2  DAZ-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_573451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC140229
      Consensus CDS
      CCDS35977.1
      UniProtKB/TrEMBL
      Q3U878
      Related
      ENSMUSP00000101001.2, ENSMUST00000105362.8
      Conserved Domains (2) summary
      cd12327
      Location:110189
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:1192
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins

    RNA

    1. NR_166396.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229
    2. NR_166397.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229
    3. NR_166398.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229
    4. NR_166399.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229
    5. NR_166400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229
    6. NR_166401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140229

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80097168..80124242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245259.2XP_030101119.1  DAZ-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:102181
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:384
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    2. XM_006514070.5XP_006514133.1  DAZ-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:103182
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:384
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    3. XM_030245258.2XP_030101118.1  DAZ-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:103182
      RRM2_DAZAP1; RNA recognition motif 2 (RRM2) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:384
      RRM1_DAZAP1; RNA recognition motif 1 (RRM1) found in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    4. XM_006514071.4XP_006514134.1  DAZ-associated protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3U878
      Conserved Domains (2) summary
      cd12327
      Location:102181
      RRM2_DAZAP1; RNA recognition motif 2 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
      cd12574
      Location:384
      RRM1_DAZAP1; RNA recognition motif 1 in Deleted in azoospermia-associated protein 1 (DAZAP1) and similar proteins
    5. XM_036155992.1XP_036011885.1  DAZ-associated protein 1 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:147
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006514072.5XP_006514135.1  DAZ-associated protein 1 isoform X5

      Conserved Domains (1) summary
      cl17169
      Location:147
      RRM_SF; RNA recognition motif (RRM) superfamily