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    Cd2bp2 CD2 cytoplasmic tail binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 70233, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cd2bp2provided by MGI
    Official Full Name
    CD2 cytoplasmic tail binding protein 2provided by MGI
    Primary source
    MGI:MGI:1917483
    See related
    Ensembl:ENSMUSG00000042502 AllianceGenome:MGI:1917483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500011B02Rik; 2410024K20Rik
    Summary
    Predicted to enable ribonucleoprotein complex binding activity. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of U5 snRNP. Predicted to colocalize with nuclear speck. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; immune system; and lung. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.7), CNS E14 (RPKM 25.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cd2bp2 in Genome Data Viewer
    Location:
    7 F3; 7 69.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126790832..126795249, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127191660..127196077, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9301 Neighboring gene sialophorin Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonucleoprotein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
     
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD2 antigen cytoplasmic tail-binding protein 2
    Names
    CD2 antigen (cytoplasmic tail) binding protein 2
    CD2 cytoplasmic domain-binding protein 2
    CD2 tail-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285905.1NP_001272834.1  CD2 antigen cytoplasmic tail-binding protein 2

      See identical proteins and their annotated locations for NP_001272834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC122537, AK034689, BM944739
      Consensus CDS
      CCDS21859.1
      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Related
      ENSMUSP00000145888.2, ENSMUST00000205316.2
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues
    2. NM_001285906.1NP_001272835.1  CD2 antigen cytoplasmic tail-binding protein 2

      See identical proteins and their annotated locations for NP_001272835.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC122537, AK030393, AK034689
      Consensus CDS
      CCDS21859.1
      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Related
      ENSMUSP00000146167.2, ENSMUST00000206026.2
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues
    3. NM_001285907.1NP_001272836.1  CD2 antigen cytoplasmic tail-binding protein 2

      See identical proteins and their annotated locations for NP_001272836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC122537, AK034689, AK167249
      Consensus CDS
      CCDS21859.1
      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Related
      ENSMUSP00000044790.4, ENSMUST00000035771.5
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues
    4. NM_001357817.1NP_001344746.1  CD2 antigen cytoplasmic tail-binding protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC122537
      Consensus CDS
      CCDS21859.1
      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues
    5. NM_027353.4NP_081629.1  CD2 antigen cytoplasmic tail-binding protein 2

      See identical proteins and their annotated locations for NP_081629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC122537, AK034689
      Consensus CDS
      CCDS21859.1
      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Related
      ENSMUSP00000132963.2, ENSMUST00000166791.8
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126790832..126795249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508198.5XP_006508261.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508261.1

      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Related
      ENSMUST00000205525.2
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues
    2. XM_030242979.2XP_030098839.1  CD2 antigen cytoplasmic tail-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TJX5, Q9CWK3
      UniProtKB/TrEMBL
      Q3U4A3
      Conserved Domains (1) summary
      smart00444
      Location:282339
      GYF; Contains conserved Gly-Tyr-Phe residues