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    Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [ Mus musculus (house mouse) ]

    Gene ID: 70122, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mllt3provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3provided by MGI
    Primary source
    MGI:MGI:1917372
    See related
    Ensembl:ENSMUSG00000028496 Vega:OTTMUSG00000007699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af9; D4Ertd321e; 2210011H10Rik; 2610012I03Rik; 3830408D16Rik
    Expression
    Broad expression in whole brain E14.5 (RPKM 9.1), CNS E14 (RPKM 9.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Mllt3 in Genome Data Viewer
    Location:
    4 C4; 4 41.06 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (87769925..88033407, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (87415829..87679311, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Neighboring gene cadherin-2 pseudogene Neighboring gene predicted gene, 34180 Neighboring gene poly(A) binding protein interacting protein 2B pseudogene Neighboring gene predicted gene, 34232 Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene 3-hydroxyacyl-CoA dehydratase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    segment specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein AF-9
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
    myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286158.1NP_001273087.1  protein AF-9 isoform 3

      See identical proteins and their annotated locations for NP_001273087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK136066, AL929524, BI202616, BY033742, BY713607, DV051568
      Consensus CDS
      CCDS71418.1
      UniProtKB/TrEMBL
      Q9D2P1
      Related
      ENSMUSP00000129523.1, OTTMUSP00000051611, ENSMUST00000126353.7, OTTMUST00000017633
    2. NM_027326.3NP_081602.3  protein AF-9 isoform 1

      See identical proteins and their annotated locations for NP_081602.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL806533, AL929524, BI202616, BU614509, CA328693, CJ052430
      Consensus CDS
      CCDS38796.1
      UniProtKB/Swiss-Prot
      A2AM29
      Related
      ENSMUSP00000077232.5, OTTMUSP00000008140, ENSMUST00000078090.11, OTTMUST00000017631
      Conserved Domains (1) summary
      pfam03366
      Location:29109
      YEATS; YEATS family
    3. NM_029931.3NP_084207.2  protein AF-9 isoform 2

      See identical proteins and their annotated locations for NP_084207.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, uses an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK019458, AK147009, AL929524, BI202616, BY033742
      Consensus CDS
      CCDS38797.1
      UniProtKB/TrEMBL
      Q3UIA3, Q9D2P1
      Related
      ENSMUSP00000128366.1, OTTMUSP00000051612, ENSMUST00000149357.7, OTTMUST00000017632

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      87769925..88033407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538250.2XP_006538313.1  protein AF-9 isoform X1

      Conserved Domains (1) summary
      pfam03366
      Location:26106
      YEATS; YEATS family
    2. XM_006538253.3XP_006538316.1  protein AF-9 isoform X2

      See identical proteins and their annotated locations for XP_006538316.1

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