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    Mllt3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [ Mus musculus (house mouse) ]

    Gene ID: 70122, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mllt3provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3provided by MGI
    Primary source
    MGI:MGI:1917372
    See related
    Ensembl:ENSMUSG00000028496 AllianceGenome:MGI:1917372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af9; D4Ertd321e; 2210011H10Rik; 2610012I03Rik; 3830408D16Rik
    Summary
    Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Acts upstream of or within anterior/posterior pattern specification; gene expression; and segment specification. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and limb bud. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 9.1), CNS E14 (RPKM 9.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mllt3 in Genome Data Viewer
    Location:
    4 C4; 4 41.06 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (87688162..87951652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (87769925..88033407, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein interacting protein 2B pseudogene Neighboring gene predicted gene, 34180 Neighboring gene predicted gene, 34232 Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene 3-hydroxyacyl-CoA dehydratase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within segment specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of super elongation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein AF-9
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
    myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286158.2NP_001273087.1  protein AF-9 isoform 3

      See identical proteins and their annotated locations for NP_001273087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AL806533, AL929524
      Consensus CDS
      CCDS71418.1
      UniProtKB/TrEMBL
      A0A8C6HS98, Q9D2P1
      Related
      ENSMUSP00000129523.2, ENSMUST00000126353.8
      Conserved Domains (1) summary
      pfam17793
      Location:81133
      AHD; ANC1 homology domain (AHD)
    2. NM_001404955.1NP_001391884.1  protein AF-9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL806533, AL831756, AL929524
    3. NM_001404956.1NP_001391885.1  protein AF-9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL806533, AL831756, AL929524
    4. NM_001404957.1NP_001391886.1  protein AF-9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL806533, AL831756, AL929524
    5. NM_001404958.1NP_001391887.1  protein AF-9 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL806533, AL929524
    6. NM_027326.4NP_081602.3  protein AF-9 isoform 1

      See identical proteins and their annotated locations for NP_081602.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL806533, AL831756, AL929524
      Consensus CDS
      CCDS38796.1
      UniProtKB/Swiss-Prot
      A2AM29, Q99MK4
      Related
      ENSMUSP00000077232.6, ENSMUST00000078090.12
      Conserved Domains (1) summary
      pfam03366
      Location:29109
      YEATS; YEATS family
    7. NM_029931.4NP_084207.2  protein AF-9 isoform 2

      See identical proteins and their annotated locations for NP_084207.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, uses an alternate 5' exon structure and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL806533, AL929524
      Consensus CDS
      CCDS38797.1
      UniProtKB/TrEMBL
      Q3UIA3, Q9D2P1
      Related
      ENSMUSP00000128366.2, ENSMUST00000149357.8
      Conserved Domains (1) summary
      pfam17793
      Location:97157
      AHD; ANC1 homology domain (AHD)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      87688162..87951652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253772.2XP_030109632.1  protein AF-9 isoform X4

      Conserved Domains (1) summary
      pfam17793
      Location:305365
      AHD; ANC1 homology domain (AHD)
    2. XM_030253771.2XP_030109631.1  protein AF-9 isoform X2

      Conserved Domains (2) summary
      cd16906
      Location:1105
      YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
      pfam17793
      Location:472532
      AHD; ANC1 homology domain (AHD)
    3. XM_036164412.1XP_036020305.1  protein AF-9 isoform X4

      Conserved Domains (1) summary
      pfam17793
      Location:305365
      AHD; ANC1 homology domain (AHD)
    4. XM_006538250.3XP_006538313.1  protein AF-9 isoform X1

      Conserved Domains (2) summary
      cd16906
      Location:6134
      YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins
      pfam17793
      Location:501561
      AHD; ANC1 homology domain (AHD)
    5. XM_030253773.1XP_030109633.1  protein AF-9 isoform X4

      Conserved Domains (1) summary
      pfam17793
      Location:305365
      AHD; ANC1 homology domain (AHD)
    6. XM_006538253.4XP_006538316.1  protein AF-9 isoform X4

      See identical proteins and their annotated locations for XP_006538316.1

      Conserved Domains (1) summary
      pfam17793
      Location:305365
      AHD; ANC1 homology domain (AHD)
    7. XM_036164411.1XP_036020304.1  protein AF-9 isoform X3

      Conserved Domains (1) summary
      cd16906
      Location:9137
      YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins