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    Smc4 structural maintenance of chromosomes 4 [ Mus musculus (house mouse) ]

    Gene ID: 70099, updated on 26-Sep-2022

    Summary

    Official Symbol
    Smc4provided by MGI
    Official Full Name
    structural maintenance of chromosomes 4provided by MGI
    Primary source
    MGI:MGI:1917349
    See related
    Ensembl:ENSMUSG00000034349 AllianceGenome:MGI:1917349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMC-4; Smc4l1; 2500002A22Rik
    Summary
    Enables chromatin binding activity and single-stranded DNA binding activity. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 30.9), CNS E11.5 (RPKM 28.6) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Smc4 in Genome Data Viewer
    Location:
    3; 3 E1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68912071..68941956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69004738..69034623)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110032F04 gene Neighboring gene intraflagellar transport 80 Neighboring gene oxysterol binding protein-like 9 pseudogene Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene tripartite motif-containing 59 Neighboring gene RIKEN cDNA 9630025H16 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of condensin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    structural maintenance of chromosomes protein 4
    Names
    SMC protein 4
    SMC4 structural maintenance of chromosomes 4-like 1
    XCAP-C homolog
    chromosome-associated polypeptide C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356976.1NP_001343905.1  structural maintenance of chromosomes protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122876, BC062939
      UniProtKB/TrEMBL
      Q6P7V9
      Conserved Domains (1) summary
      pfam02463
      Location:111202
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_133786.4NP_598547.1  structural maintenance of chromosomes protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598547.1

      Status: VALIDATED

      Source sequence(s)
      AC122876, BC062939, CN722683
      Consensus CDS
      CCDS17401.1
      UniProtKB/Swiss-Prot
      Q8CG47, Q99K21
      Related
      ENSMUSP00000047872.9, ENSMUST00000042901.15
      Conserved Domains (1) summary
      pfam02463
      Location:811272
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      68912071..68941956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252813.2XP_030108673.1  structural maintenance of chromosomes protein 4 isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:111042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_006502046.3XP_006502109.1  structural maintenance of chromosomes protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006502109.1

      UniProtKB/Swiss-Prot
      Q8CG47, Q99K21
      Conserved Domains (1) summary
      pfam02463
      Location:811272
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_030252812.2XP_030108672.1  structural maintenance of chromosomes protein 4 isoform X2

      UniProtKB/TrEMBL
      Q6P7V9
      Conserved Domains (1) summary
      pfam02463
      Location:111202
      SMC_N; RecF/RecN/SMC N terminal domain
    4. XM_036163300.1XP_036019193.1  structural maintenance of chromosomes protein 4 isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:111042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    5. XM_036163301.1XP_036019194.1  structural maintenance of chromosomes protein 4 isoform X3

      Conserved Domains (1) summary
      COG1196
      Location:111042
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]