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    Sash1 SAM and SH3 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70097, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sash1provided by MGI
    Official Full Name
    SAM and SH3 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1917347
    See related
    Ensembl:ENSMUSG00000015305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0790; 1100001C18Rik; 2500002E12Rik; A330076K04Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 10.4), subcutaneous fat pad adult (RPKM 8.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sash1 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (8597981..8821290, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (8722217..8945608, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (8442017..8605868, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53611 Neighboring gene uronyl-2-sulfotransferase Neighboring gene predicted gene, 24374 Neighboring gene predicted gene, 25410 Neighboring gene predicted gene, 48727 Neighboring gene predicted gene, 51794 Neighboring gene sterile alpha motif domain containing 5 Neighboring gene predicted gene, 48750

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of NIK/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    SAM and SH3 domain-containing protein 1
    Names
    putative adapter and scaffold protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175155.4NP_780364.3  SAM and SH3 domain-containing protein 1

      See identical proteins and their annotated locations for NP_780364.3

      Status: VALIDATED

      Source sequence(s)
      AJ507736, BY770549, CJ125950
      Consensus CDS
      CCDS23692.1
      UniProtKB/Swiss-Prot
      P59808
      UniProtKB/TrEMBL
      F8VQK5
      Related
      ENSMUSP00000015449.6, ENSMUST00000015449.6
      Conserved Domains (5) summary
      cd09492
      Location:11561225
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:627691
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:11611224
      SAM; Sterile alpha motif
      cd11967
      Location:550606
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:394548
      SLY; Lymphocyte signaling adaptor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      8597981..8821290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245256.2XP_030101116.1  SAM and SH3 domain-containing protein 1 isoform X2

      Conserved Domains (5) summary
      cd09492
      Location:12801349
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:751815
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:674730
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:8171176
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:521672
      SLY; Lymphocyte signaling adaptor protein
    2. XM_006512837.4XP_006512900.1  SAM and SH3 domain-containing protein 1 isoform X4

      Conserved Domains (5) summary
      cd09492
      Location:11181187
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:589653
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:512568
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:6551014
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:356510
      SLY; Lymphocyte signaling adaptor protein
    3. XM_030245255.2XP_030101115.1  SAM and SH3 domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd09492
      Location:13181387
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:789853
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:712768
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:8551214
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:559710
      SLY; Lymphocyte signaling adaptor protein
    4. XM_036155989.1XP_036011882.1  SAM and SH3 domain-containing protein 1 isoform X3

      Conserved Domains (5) summary
      cd09492
      Location:12451314
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:716780
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:639695
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:7821141
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:485637
      SLY; Lymphocyte signaling adaptor protein
    5. XM_006512840.3XP_006512903.1  SAM and SH3 domain-containing protein 1 isoform X8

      Conserved Domains (5) summary
      cd09492
      Location:924993
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:395459
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:318374
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:461820
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:162316
      SLY; Lymphocyte signaling adaptor protein
    6. XM_030245257.1XP_030101117.1  SAM and SH3 domain-containing protein 1 isoform X6

      Conserved Domains (5) summary
      cd09492
      Location:10861155
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:557621
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:480536
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:623982
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:327478
      SLY; Lymphocyte signaling adaptor protein
    7. XM_006512841.3XP_006512904.2  SAM and SH3 domain-containing protein 1 isoform X5

      Conserved Domains (5) summary
      cd09492
      Location:10981167
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:569633
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:492548
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03307
      Location:635994
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12485
      Location:339490
      SLY; Lymphocyte signaling adaptor protein
    8. XM_006512839.5XP_006512902.1  SAM and SH3 domain-containing protein 1 isoform X7

      Conserved Domains (5) summary
      cd09492
      Location:9361005
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:407471
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:330386
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:600846
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:174328
      SLY; Lymphocyte signaling adaptor protein
    9. XM_036155990.1XP_036011883.1  SAM and SH3 domain-containing protein 1 isoform X9

      Conserved Domains (6) summary
      PTZ00449
      Location:474588
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09492
      Location:703772
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:174238
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      cd11967
      Location:97153
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      PHA03247
      Location:367613
      PHA03247; large tegument protein UL36; Provisional
      pfam12485
      Location:195
      SLY; Lymphocyte signaling adaptor protein
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