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    Sash1 SAM and SH3 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70097, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sash1provided by MGI
    Official Full Name
    SAM and SH3 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1917347
    See related
    Ensembl:ENSMUSG00000015305 Vega:OTTMUSG00000062029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0790; 1100001C18Rik; 2500002E12Rik; A330076K04Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 10.4), subcutaneous fat pad adult (RPKM 8.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sash1 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (8722217..9027745, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (8442017..8605868, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245105 Neighboring gene uronyl-2-sulfotransferase Neighboring gene predicted gene, 40600 Neighboring gene sterile alpha motif domain containing 5 Neighboring gene predicted gene 6150

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    mitogen-activated protein kinase kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    SAM and SH3 domain-containing protein 1
    Names
    putative adapter and scaffold protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175155.4NP_780364.3  SAM and SH3 domain-containing protein 1

      See identical proteins and their annotated locations for NP_780364.3

      Status: VALIDATED

      Source sequence(s)
      AJ507736, BY770549, CJ125950
      Consensus CDS
      CCDS23692.1
      UniProtKB/Swiss-Prot
      P59808
      UniProtKB/TrEMBL
      F8VQK5
      Related
      ENSMUSP00000015449.5, OTTMUSP00000078540, ENSMUST00000015449.5, OTTMUST00000151442
      Conserved Domains (5) summary
      cd09492
      Location:11561225
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:627691
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:11611224
      SAM; Sterile alpha motif
      cd11967
      Location:550606
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:394548
      SLY; Lymphocyte signaling adaptor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      8722217..9027745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314079.1XP_017169568.1  SAM and SH3 domain-containing protein 1 isoform X2

    2. XM_011243205.1XP_011241507.1  SAM and SH3 domain-containing protein 1 isoform X1

      Conserved Domains (5) summary
      cd09492
      Location:12271296
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:698762
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:12321295
      SAM; Sterile alpha motif
      cd11967
      Location:621677
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:465619
      SLY; Lymphocyte signaling adaptor protein
    3. XM_006512837.2XP_006512900.1  SAM and SH3 domain-containing protein 1 isoform X3

      Conserved Domains (5) summary
      cd09492
      Location:11181187
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:589653
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:11231186
      SAM; Sterile alpha motif
      cd11967
      Location:512568
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:356510
      SLY; Lymphocyte signaling adaptor protein
    4. XM_006512840.2XP_006512903.1  SAM and SH3 domain-containing protein 1 isoform X5

      Conserved Domains (5) summary
      cd09492
      Location:924993
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:395459
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:929992
      SAM; Sterile alpha motif
      cd11967
      Location:318374
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:162316
      SLY; Lymphocyte signaling adaptor protein
    5. XM_006512839.3XP_006512902.1  SAM and SH3 domain-containing protein 1 isoform X4

      Conserved Domains (5) summary
      cd09492
      Location:9361005
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:407471
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:9411004
      SAM; Sterile alpha motif
      cd11967
      Location:330386
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:174328
      SLY; Lymphocyte signaling adaptor protein
    6. XM_006512841.1XP_006512904.1  SAM and SH3 domain-containing protein 1 isoform X6

      Conserved Domains (5) summary
      cd09492
      Location:703772
      SAM_SASH1_repeat2; SAM domain of SASH1 proteins, repeat 2
      cd09559
      Location:174238
      SAM_SASH1_repeat1; SAM domain of SASH1 proteins, repeat 1
      smart00454
      Location:708771
      SAM; Sterile alpha motif
      cd11967
      Location:97153
      SH3_SASH1; Src homology 3 domain of SAM And SH3 Domain Containing Protein 1
      pfam12485
      Location:195
      SLY; Lymphocyte signaling adaptor protein
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