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    Meaf6 MYST/Esa1-associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 70088, updated on 2-Oct-2018

    Summary

    Official Symbol
    Meaf6provided by MGI
    Official Full Name
    MYST/Esa1-associated factor 6provided by MGI
    Primary source
    MGI:MGI:1917338
    See related
    Ensembl:ENSMUSG00000028863 Vega:OTTMUSG00000009252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310005N01Rik; 2810036M01Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Meaf6 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (125085132..125110070)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124762391..124787133)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene zinc finger CCCH type containing 12A Neighboring gene predicted gene, 40246 Neighboring gene predicted gene, 32611

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity (H3-K23 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2A acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K14 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K12 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    NuA3a histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NuA3b histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chromatin modification-related protein MEAF6
    Names
    esa1-associated factor 6 homolog
    protein EAF6 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290701.2NP_001277630.1  chromatin modification-related protein MEAF6 isoform 2

      See identical proteins and their annotated locations for NP_001277630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in 3' coding region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS71467.1
      UniProtKB/Swiss-Prot
      Q2VPQ9
      Related
      ENSMUSP00000122288.1, OTTMUSP00000009600, ENSMUST00000154689.7
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4
    2. NM_027310.5NP_081586.1  chromatin modification-related protein MEAF6 isoform 1

      See identical proteins and their annotated locations for NP_081586.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS18637.1
      UniProtKB/Swiss-Prot
      Q2VPQ9
      Related
      ENSMUSP00000053543.4, OTTMUSP00000009604, ENSMUST00000055213.10
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4

    RNA

    1. NR_151472.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, AW123768, BY133395, BY600332, CX220687

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      125085132..125110070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503382.3XP_006503445.1  chromatin modification-related protein MEAF6 isoform X2

      See identical proteins and their annotated locations for XP_006503445.1

      Related
      ENSMUSP00000101777.3, OTTMUSP00000009603, ENSMUST00000106171.8, OTTMUST00000020950
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4
    2. XM_006503381.3XP_006503444.1  chromatin modification-related protein MEAF6 isoform X1

      Conserved Domains (1) summary
      pfam09340
      Location:1794
      NuA4; Histone acetyltransferase subunit NuA4

    RNA

    1. XR_376353.3 RNA Sequence

    2. XR_376354.3 RNA Sequence

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