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    Meaf6 MYST/Esa1-associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 70088, updated on 23-Jun-2021

    Summary

    Official Symbol
    Meaf6provided by MGI
    Official Full Name
    MYST/Esa1-associated factor 6provided by MGI
    Primary source
    MGI:MGI:1917338
    See related
    Ensembl:ENSMUSG00000028863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310005N01Rik; 2810036M01Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Meaf6 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124978883..125007031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125085113..125113238)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124762391..124787133)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene zinc finger CCCH type containing 12A Neighboring gene predicted gene, 40246 Neighboring gene predicted gene, 32611

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H2A acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-K14 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K12 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K12 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K5 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H4-K8 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA3a histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA3b histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chromatin modification-related protein MEAF6
    Names
    esa1-associated factor 6 homolog
    protein EAF6 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290701.2NP_001277630.1  chromatin modification-related protein MEAF6 isoform 2

      See identical proteins and their annotated locations for NP_001277630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in 3' coding region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS71467.1
      UniProtKB/Swiss-Prot
      Q2VPQ9
      Related
      ENSMUSP00000122288.2, ENSMUST00000154689.8
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4
    2. NM_001374123.1NP_001361052.1  chromatin modification-related protein MEAF6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, BQ178199, CO428776
      Related
      ENSMUSP00000101777.4, ENSMUST00000106171.9
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4
    3. NM_027310.5NP_081586.1  chromatin modification-related protein MEAF6 isoform 1

      See identical proteins and their annotated locations for NP_081586.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS18637.1
      UniProtKB/Swiss-Prot
      Q2VPQ9
      Related
      ENSMUSP00000053543.5, ENSMUST00000055213.11
      Conserved Domains (1) summary
      pfam09340
      Location:1896
      NuA4; Histone acetyltransferase subunit NuA4

    RNA

    1. NR_151472.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, AW123768, BY133395, BY600332, CX220687
    2. NR_164336.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, BQ178199, CD353468

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124978883..125007031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955011.2 RNA Sequence

    2. XR_003955012.2 RNA Sequence

    3. XR_004941956.1 RNA Sequence

    4. XR_003955014.2 RNA Sequence

    5. XR_003955013.2 RNA Sequence

    6. XR_004941957.1 RNA Sequence

    7. XR_004941958.1 RNA Sequence

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