Acot7 acyl-CoA thioesterase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot7provided by MGI
Official Full Name: acyl-CoA thioesterase 7provided by MGI
Primary source: MGI:MGI:1917275
See related: Ensembl:ENSMUSG00000028937 AllianceGenome:MGI:1917275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Act; Ach1; Bach; Lach1; Cte-II; CTE-IIa; 2410041A17Rik
Summary: Enables identical protein binding activity and palmitoyl-CoA hydrolase activity. Acts upstream of or within fatty acid catabolic process. Located in several cellular components, including cell body; cytosol; and mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT7 (acyl-CoA thioesterase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 205.9), cerebellum adult (RPKM 88.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 82.93 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152258872..152356312)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (152178100..152271855)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acot7, a fatty acid metabolic enzyme highly enriched in neurons, regulates both brain-specific metabolic processes related to seizure susceptibility and the whole body response to dietary lipid
Title: Loss of ACOT7 potentiates seizures and metabolic dysfunction.
downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells
Title: Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages.
Data (including data from studies in transgenic mice) suggest that up-regulation of Acot7 expression in clonal beta-cells impairs insulin secretion in response to glucose plus free fatty acids; expression of Acot7 is ubiquitous across tissues but relatively silenced/disallowed in pancreatic beta cells.
Title: Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.
ACOT7 may be involved in dietary intake-associated responses in fatty acid metabolism in mesenteric lymph nodes.
Title: Identification of acyl-CoA thioesterase in mouse mesenteric lymph nodes.
ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity.
Title: Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity.
mBACH cDNA encoded a 338-AA pp >95% identical to human and rat homologs. mBACH was distributed throughboth central and peripheral cell body and neurites. Another 50-kDa pp made from mBACH mRNA used different in-frame ATGs as initiation codon.
Title: Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization.
Acot7 gene is expressed as multiple isoforms in a tissue-specific manner; expression in tissues other than brain and testis is likely to play important roles in fatty acid metabolism.
Title: Alternative exon usage selectively determines both tissue distribution and subcellular localization of the acyl-CoA thioesterase 7 gene products.
The structural basis for recruitmment of tandem domains in Acot7 is demonstrated and its role in inflammation presented.
Title: Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acot7 (e-PCR), detects polymorphism
- UniSTS:546626

AU042212 (e-PCR)
- UniSTS:159331

AU014716 (e-PCR)
- UniSTS:207730

RH126892 (e-PCR)
- UniSTS:207733

D1S2335E (e-PCR)
- UniSTS:147361

AW557066 (e-PCR)
- UniSTS:179118

ACOT7 (e-PCR)
- UniSTS:503283

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables myristoyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in coenzyme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fatty acid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in medium-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in palmitic acid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic acyl coenzyme A thioester hydrolase

Names: 50-kDa brain acyl-CoA hydrolase; brain acyl-CoA hydrolase; long chain acyl-CoA thioester hydrolase

NP_001139529.2

EC 3.1.2.2

NP_001139530.1

EC 3.1.2.2

NP_001356202.1

EC 3.1.2.2

NP_001356203.1

EC 3.1.2.2

NP_001356204.1

EC 3.1.2.2

NP_001356205.1

EC 3.1.2.2

NP_579926.2

EC 3.1.2.2

XP_006539232.1

EC 3.1.2.2

XP_030109627.1

EC 3.1.2.2

XP_030109628.1

EC 3.1.2.2

XP_030109629.1

EC 3.1.2.2

XP_036020303.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146057.2 → NP_001139529.2 cytosolic acyl coenzyme A thioester hydrolase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL611985, AL671869, AL772240

Consensus CDS

CCDS51391.2

UniProtKB/Swiss-Prot

A2A8K9, A2A8L0, A2A8L2, Q3U8C6, Q59HQ2, Q91V12

UniProtKB/TrEMBL

E9PYH2

Related

ENSMUSP00000030779.4, ENSMUST00000030779.10

Conserved Domains (2) summary

cd03442
Location:223 → 346

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:183 → 208

NINJA_B; Putative nuclear localization signal
NM_001146058.1 → NP_001139530.1 cytosolic acyl coenzyme A thioester hydrolase isoform 3

See identical proteins and their annotated locations for NP_001139530.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (3) with a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK152277, BQ748599, CX225643, CX235974

Consensus CDS

CCDS51392.1

UniProtKB/TrEMBL

E9PYH2

Related

ENSMUSP00000101277.3, ENSMUST00000105652.3

Conserved Domains (2) summary

cd03442
Location:192 → 315

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:152 → 177

NINJA_B; Putative nuclear localization signal
NM_001369273.1 → NP_001356202.1 cytosolic acyl coenzyme A thioester hydrolase isoform 4

Status: VALIDATED

Source sequence(s)

AL611985, AL671869, AL772240

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (2) summary

cd03442
Location:180 → 305

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:140 → 165

NINJA_B; Putative nuclear localization signal
NM_001369274.1 → NP_001356203.1 cytosolic acyl coenzyme A thioester hydrolase isoform 5

Status: VALIDATED

Source sequence(s)

AL611985, AL671869, AL772240

Conserved Domains (2) summary

cd03442
Location:180 → 303

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:140 → 165

NINJA_B; Putative nuclear localization signal
NM_001369275.1 → NP_001356204.1 cytosolic acyl coenzyme A thioester hydrolase isoform 6

Status: VALIDATED

Source sequence(s)

AL611985, AL671869, AL772240

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (2) summary

cd03442
Location:165 → 288

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:125 → 150

NINJA_B; Putative nuclear localization signal
NM_001369276.1 → NP_001356205.1 cytosolic acyl coenzyme A thioester hydrolase isoform 7

Status: VALIDATED

Source sequence(s)

AL611985, AL671869, AL772240

Conserved Domains (2) summary

cd03442
Location:16 → 121

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:140 → 165

NINJA_B; Putative nuclear localization signal
NM_133348.2 → NP_579926.2 cytosolic acyl coenzyme A thioester hydrolase isoform 2

See identical proteins and their annotated locations for NP_579926.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK152277, BQ748599, CA463703, CX235974

Consensus CDS

CCDS51390.1

UniProtKB/TrEMBL

E9PYH2

Related

ENSMUSP00000074827.4, ENSMUST00000075363.10

Conserved Domains (2) summary

cd03442
Location:221 → 344

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

pfam16136
Location:181 → 206

NINJA_B; Putative nuclear localization signal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

152258872..152356312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164410.1 → XP_036020303.1 cytosolic acyl coenzyme A thioester hydrolase isoform X2

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (1) summary

cd03442
Location:163 → 286

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_030253767.2 → XP_030109627.1 cytosolic acyl coenzyme A thioester hydrolase isoform X1

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (1) summary

cd03442
Location:171 → 294

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_030253769.2 → XP_030109629.1 cytosolic acyl coenzyme A thioester hydrolase isoform X2

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (1) summary

cd03442
Location:163 → 286

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_030253768.2 → XP_030109628.1 cytosolic acyl coenzyme A thioester hydrolase isoform X2

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (1) summary

cd03442
Location:163 → 286

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
XM_006539169.2 → XP_006539232.1 cytosolic acyl coenzyme A thioester hydrolase isoform X2

UniProtKB/TrEMBL

E9PYH2

Conserved Domains (1) summary

cd03442
Location:163 → 286

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...