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    Acot7 acyl-CoA thioesterase 7 [ Mus musculus (house mouse) ]

    Gene ID: 70025, updated on 19-Feb-2019

    Summary

    Official Symbol
    Acot7provided by MGI
    Official Full Name
    acyl-CoA thioesterase 7provided by MGI
    Primary source
    MGI:MGI:1917275
    See related
    Ensembl:ENSMUSG00000028937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Act; Ach1; Bach; Lach1; Cte-II; CTE-IIa; 2410041A17Rik
    Expression
    Broad expression in testis adult (RPKM 205.9), cerebellum adult (RPKM 88.3) and 17 other tissues See more
    Orthologs

    Genomic context

    See Acot7 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (152178100..152271855)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (151552209..151645964)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30622 Neighboring gene hes family bHLH transcription factor 2 Neighboring gene G protein-coupled receptor 153 Neighboring gene hes family bHLH transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    long-chain fatty acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    long-chain fatty acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    myristoyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitoyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    palmitoyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    medium-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    medium-chain fatty-acyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    palmitic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic acyl coenzyme A thioester hydrolase
    Names
    50-kDa brain acyl-CoA hydrolase
    brain acyl-CoA hydrolase
    long chain acyl-CoA thioester hydrolase
    NP_001139529.1
    NP_001139530.1
    NP_579926.2
    XP_006539232.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146057.1NP_001139529.1  cytosolic acyl coenzyme A thioester hydrolase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK152277, BQ748599, BY134190, BY327697, CX235974
      Consensus CDS
      CCDS51391.1
      UniProtKB/Swiss-Prot
      Q91V12
      UniProtKB/TrEMBL
      E9PYH2
      Related
      ENSMUSP00000129121.1, ENSMUST00000167926.7
      Conserved Domains (2) summary
      cd03442
      Location:226349
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      pfam16136
      Location:186211
      NINJA_B; Putative nuclear localization signal
    2. NM_001146058.1NP_001139530.1  cytosolic acyl coenzyme A thioester hydrolase isoform 3

      See identical proteins and their annotated locations for NP_001139530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (3) with a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK152277, BQ748599, CX225643, CX235974
      Consensus CDS
      CCDS51392.1
      UniProtKB/Swiss-Prot
      Q91V12
      Related
      ENSMUSP00000101277.2, ENSMUST00000105652.2
      Conserved Domains (2) summary
      cd03442
      Location:192315
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      pfam16136
      Location:152177
      NINJA_B; Putative nuclear localization signal
    3. NM_133348.2NP_579926.2  cytosolic acyl coenzyme A thioester hydrolase isoform 2

      See identical proteins and their annotated locations for NP_579926.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK152277, BQ748599, CA463703, CX235974
      Consensus CDS
      CCDS51390.1
      UniProtKB/Swiss-Prot
      Q91V12
      Related
      ENSMUSP00000074827.3, ENSMUST00000075363.9
      Conserved Domains (2) summary
      cd03442
      Location:221344
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      pfam16136
      Location:181206
      NINJA_B; Putative nuclear localization signal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      152178100..152271855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539169.2XP_006539232.1  cytosolic acyl coenzyme A thioester hydrolase isoform X1

      Conserved Domains (2) summary
      cd03442
      Location:163286
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      pfam16136
      Location:123148
      NINJA_B; Putative nuclear localization signal
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