U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Mcm10 minichromosome maintenance 10 replication initiation factor [ Mus musculus (house mouse) ]

    Gene ID: 70024, updated on 13-Oct-2022

    Summary

    Official Symbol
    Mcm10provided by MGI
    Official Full Name
    minichromosome maintenance 10 replication initiation factorprovided by MGI
    Primary source
    MGI:MGI:1917274
    See related
    Ensembl:ENSMUSG00000026669 AllianceGenome:MGI:1917274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410041F14Rik; C330019M07Rik
    Summary
    Enables enzyme binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of replication fork protection complex. Is expressed in several structures, including cerebellum; early conceptus; gonad; immune system; and liver. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 7.2), CNS E11.5 (RPKM 6.2) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mcm10 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4995535..5017602, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4990724..5012791, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated Neighboring gene optineurin Neighboring gene predicted gene, 39755

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein MCM10 homolog
    Names
    minichromosome maintenance deficient 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305259.1NP_001292188.1  protein MCM10 homolog

      See identical proteins and their annotated locations for NP_001292188.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC064314
      Consensus CDS
      CCDS15662.1
      UniProtKB/Swiss-Prot
      Q0VBD2, Q8BYA7
      Related
      ENSMUSP00000100050.2, ENSMUST00000102985.8
      Conserved Domains (2) summary
      pfam09329
      Location:398443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544883
      Mcm10; Mcm10 replication factor
    2. NM_027290.3NP_081566.2  protein MCM10 homolog

      See identical proteins and their annotated locations for NP_081566.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK030780, BC094576, BE951862
      Consensus CDS
      CCDS15662.1
      UniProtKB/Swiss-Prot
      Q0VBD2, Q8BYA7
      Related
      ENSMUSP00000027980.8, ENSMUST00000027980.8
      Conserved Domains (2) summary
      pfam09329
      Location:398443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544883
      Mcm10; Mcm10 replication factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      4995535..5017602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162558.1XP_036018451.1  protein MCM10 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8BYA7
      Conserved Domains (2) summary
      pfam09329
      Location:398443
      zf-primase; Primase zinc finger
      pfam09332
      Location:544883
      Mcm10; Mcm10 replication factor