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    Rsc1a1 regulatory solute carrier protein, family 1, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 69994, updated on 18-Sep-2024

    Summary

    Official Symbol
    Rsc1a1provided by MGI
    Official Full Name
    regulatory solute carrier protein, family 1, member 1provided by MGI
    Primary source
    MGI:MGI:3526447
    See related
    Ensembl:ENSMUSG00000040715 AllianceGenome:MGI:3526447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rs1; 1700027M01Rik
    Summary
    Predicted to enable sodium channel inhibitor activity. Acts upstream of or within intestinal absorption and negative regulation of protein localization to plasma membrane. Located in brush border and membrane. Used to study obesity. Orthologous to human RSC1A1 (regulator of solute carriers 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Rsc1a1 in Genome Data Viewer
    Location:
    4 D3; 4 74.7 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141410874..141413027, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141683563..141685716, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:141180986-141181286 Neighboring gene solute carrier family 25, member 34 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 2 Neighboring gene predicted gene, 54266 Neighboring gene STARR-seq mESC enhancer starr_11927 Neighboring gene DNA-damage inducible protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11263 Neighboring gene predicted gene, 34863 Neighboring gene STARR-seq mESC enhancer starr_11931 Neighboring gene agmatinase

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regulatory solute carrier protein family 1 member 1
    Names
    regulatory subunit of SGLT1
    transporter regulator RS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023544.5NP_076033.4  regulatory solute carrier protein family 1 member 1

      See identical proteins and their annotated locations for NP_076033.4

      Status: VALIDATED

      Source sequence(s)
      AI854132, AL671733
      Consensus CDS
      CCDS18879.1
      UniProtKB/Swiss-Prot
      B1AUM1, B2RWX9, Q78HA0, Q9CVU8, Q9ER99
      Related
      ENSMUSP00000101408.2, ENSMUST00000105782.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      141410874..141413027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)