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    Exoc1 exocyst complex component 1 [ Mus musculus (house mouse) ]

    Gene ID: 69940, updated on 14-Sep-2021

    Summary

    Official Symbol
    Exoc1provided by MGI
    Official Full Name
    exocyst complex component 1provided by MGI
    Primary source
    MGI:MGI:2445020
    See related
    Ensembl:ENSMUSG00000036435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SEC; SEC3; Sec3p; Sec3l1; 2810407P21Rik; A730011E05Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Exoc1 in Genome Data Viewer
    Location:
    5 C3.3; 5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76677147..76718145)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76529307..76570298)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (76958348..76999310)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34175 Neighboring gene neuromedin U Neighboring gene predicted gene 7271 Neighboring gene centrosomal protein 135 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene uncharacterized LOC118567351 Neighboring gene ribosomal protein L23a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    exocyst complex component 1
    Names
    SEC3-like 1
    exocyst complex component Sec3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289770.1NP_001276699.1  exocyst complex component 1 isoform 2

      See identical proteins and their annotated locations for NP_001276699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS71607.1
      UniProtKB/Swiss-Prot
      Q8R3S6
      UniProtKB/TrEMBL
      Q6P1Y9
      Related
      ENSMUSP00000084373.5, ENSMUST00000087133.11
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184871
      Sec3_C; Exocyst complex component Sec3
    2. NM_001289771.1NP_001276700.1  exocyst complex component 1 isoform 3

      See identical proteins and their annotated locations for NP_001276700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS71608.1
      UniProtKB/TrEMBL
      Q5PPR2, Q6P1Y9
      Related
      ENSMUSP00000046719.7, ENSMUST00000049469.13
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184856
      Sec3_C; Exocyst complex component Sec3
    3. NM_001359370.1NP_001346299.1  exocyst complex component 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191881
      Sec3_C; Exocyst complex component Sec3
    4. NM_001359372.1NP_001346301.1  exocyst complex component 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191863
      Sec3_C; Exocyst complex component Sec3
    5. NM_001359373.1NP_001346302.1  exocyst complex component 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC127332, AK042620
      Related
      ENSMUST00000137018.8
      Conserved Domains (1) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
    6. NM_027270.2NP_081546.1  exocyst complex component 1 isoform 1

      See identical proteins and their annotated locations for NP_081546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS39117.1
      UniProtKB/TrEMBL
      Q6P1Y9
      Related
      ENSMUSP00000109121.2, ENSMUST00000113493.8
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191878
      Sec3_C; Exocyst complex component Sec3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      76677147..76718145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165480.1XP_036021373.1  exocyst complex component 1 isoform X3

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184889
      Sec3_C; Exocyst complex component Sec3
    2. XM_036165478.1XP_036021371.1  exocyst complex component 1 isoform X1

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195900
      Sec3_C; Exocyst complex component Sec3
    3. XM_036165481.1XP_036021374.1  exocyst complex component 1 isoform X4

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195885
      Sec3_C; Exocyst complex component Sec3
    4. XM_036165479.1XP_036021372.1  exocyst complex component 1 isoform X2

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191896
      Sec3_C; Exocyst complex component Sec3
    5. XM_036165484.1XP_036021377.1  exocyst complex component 1 isoform X7

      Conserved Domains (1) summary
      cl19950
      Location:25512
      Sec3_C; Exocyst complex component Sec3
    6. XM_036165485.1XP_036021378.1  exocyst complex component 1 isoform X7

      Conserved Domains (1) summary
      cl19950
      Location:25512
      Sec3_C; Exocyst complex component Sec3
    7. XM_036165482.1XP_036021375.1  exocyst complex component 1 isoform X5

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195882
      Sec3_C; Exocyst complex component Sec3
    8. XM_036165483.1XP_036021376.1  exocyst complex component 1 isoform X6

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195867
      Sec3_C; Exocyst complex component Sec3
    9. XM_036165486.1XP_036021379.1  exocyst complex component 1 isoform X8

      Conserved Domains (1) summary
      cl19950
      Location:6494
      Sec3_C; Exocyst complex component Sec3
    10. XM_036165487.1XP_036021380.1  exocyst complex component 1 isoform X9

      Conserved Domains (1) summary
      cl19950
      Location:6479
      Sec3_C; Exocyst complex component Sec3
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