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    Exoc1 exocyst complex component 1 [ Mus musculus (house mouse) ]

    Gene ID: 69940, updated on 5-Aug-2018

    Summary

    Official Symbol
    Exoc1provided by MGI
    Official Full Name
    exocyst complex component 1provided by MGI
    Primary source
    MGI:MGI:2445020
    See related
    Ensembl:ENSMUSG00000036435 Vega:OTTMUSG00000026487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SEC3; Sec3p; Sec3l1; 2810407P21Rik; A730011E05Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Exoc1 in Genome Data Viewer
    Location:
    5 C3.3; 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (76529307..76570298)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (76958348..76999310)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34175 Neighboring gene neuromedin U Neighboring gene predicted gene 7271 Neighboring gene centrosomal protein 135 Neighboring gene RIKEN cDNA A730089K16 gene Neighboring gene RIKEN cDNA C530008M17 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP-Rho binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exocyst localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    exocyst complex component 1
    Names
    SEC3-like 1
    exocyst complex component Sec3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289770.1NP_001276699.1  exocyst complex component 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS71607.1
      UniProtKB/Swiss-Prot
      Q8R3S6
      UniProtKB/TrEMBL
      Q6P1Y9
      Related
      ENSMUSP00000084373.4, OTTMUSP00000032646, ENSMUST00000087133.10, OTTMUST00000065490
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184871
      Sec3_C; Exocyst complex component Sec3
    2. NM_001289771.1NP_001276700.1  exocyst complex component 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS71608.1
      UniProtKB/TrEMBL
      Q5PPR2, Q6P1Y9
      Related
      ENSMUSP00000046719.6, OTTMUSP00000032648, ENSMUST00000049469.12, OTTMUST00000065492
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184856
      Sec3_C; Exocyst complex component Sec3
    3. NM_001359370.1NP_001346299.1  exocyst complex component 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191881
      Sec3_C; Exocyst complex component Sec3
    4. NM_001359372.1NP_001346301.1  exocyst complex component 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191863
      Sec3_C; Exocyst complex component Sec3
    5. NM_001359373.1NP_001346302.1  exocyst complex component 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC127332, AK042620
      Conserved Domains (1) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
    6. NM_027270.2NP_081546.1  exocyst complex component 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      BB757059, BB842768, BC064811
      Consensus CDS
      CCDS39117.1
      UniProtKB/TrEMBL
      Q6P1Y9
      Related
      ENSMUSP00000109121.1, OTTMUSP00000032647, ENSMUST00000113493.7, OTTMUST00000065491
      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191878
      Sec3_C; Exocyst complex component Sec3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      76529307..76570298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535212.2XP_006535275.1  exocyst complex component 1 isoform X1

      Conserved Domains (2) summary
      cd14683
      Location:3120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191863
      Sec3_C; Exocyst complex component Sec3
    2. XM_006535214.2XP_006535277.1  exocyst complex component 1 isoform X2

      Conserved Domains (1) summary
      cl19950
      Location:6494
      Sec3_C; Exocyst complex component Sec3
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