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    Cenps centromere protein S [ Mus musculus (house mouse) ]

    Gene ID: 69928, updated on 25-Nov-2021

    Summary

    Official Symbol
    Cenpsprovided by MGI
    Official Full Name
    centromere protein Sprovided by MGI
    Primary source
    MGI:MGI:1917178
    See related
    Ensembl:ENSMUSG00000073705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apitd1; CENP-S; 2610040C18Rik; 2810407L01Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 11.2), liver E14 (RPKM 8.1) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Cenps in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149212806..149222057, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149128349..149137600, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148502458..148511709, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor, alpha subunit Neighboring gene cortistatin Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene phosphogluconate dehydrogenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC58422

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of FANCM-MHF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centromere protein S
    Names
    FANCM-interacting histone fold protein 1
    apoptosis-inducing TAF9-like domain-containing protein 1 homolog
    apoptosis-inducing, TAF9-like domain 1
    ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027263.2NP_081539.1  centromere protein S

      See identical proteins and their annotated locations for NP_081539.1

      Status: VALIDATED

      Source sequence(s)
      AK011725, DV656255
      Consensus CDS
      CCDS18954.1
      UniProtKB/Swiss-Prot
      Q9D084
      Related
      ENSMUSP00000030813.4, ENSMUST00000030813.10
      Conserved Domains (1) summary
      pfam15630
      Location:1691
      CENP-S; Kinetochore component CENP-S

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149212806..149222057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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