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    Agk acylglycerol kinase [ Mus musculus (house mouse) ]

    Gene ID: 69923, updated on 31-Jan-2019

    Summary

    Official Symbol
    Agkprovided by MGI
    Official Full Name
    acylglycerol kinaseprovided by MGI
    Primary source
    MGI:MGI:1917173
    See related
    Ensembl:ENSMUSG00000029916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mulk; AI465370; 2610037M15Rik; 6720408I04Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.1), CNS E14 (RPKM 4.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Agk in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (40325155..40397562)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (40275477..40346761)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene transmembrane protein 178B Neighboring gene RIKEN cDNA E330009J07 gene Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene single-stranded DNA binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    acylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acylglycerol kinase, mitochondrial
    Names
    multi-substrate lipid kinase
    multiple substrate lipid kinase
    NP_076027.1
    XP_006506634.1
    XP_011239760.1
    XP_017177222.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023538.2NP_076027.1  acylglycerol kinase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_076027.1

      Status: VALIDATED

      Source sequence(s)
      AC153728
      Consensus CDS
      CCDS20027.1
      UniProtKB/Swiss-Prot
      Q9ESW4
      Related
      ENSMUSP00000031977.8, ENSMUST00000031977.11
      Conserved Domains (1) summary
      pfam00781
      Location:62195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      40325155..40397562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506571.2XP_006506634.1  acylglycerol kinase, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam00781
      Location:1103
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_011241458.1XP_011239760.1  acylglycerol kinase, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00781
      Location:62183
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. XM_017321733.1XP_017177222.1  acylglycerol kinase, mitochondrial isoform X3

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