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    Agk acylglycerol kinase [ Mus musculus (house mouse) ]

    Gene ID: 69923, updated on 16-Oct-2021

    Summary

    Official Symbol
    Agkprovided by MGI
    Official Full Name
    acylglycerol kinaseprovided by MGI
    Primary source
    MGI:MGI:1917173
    See related
    Ensembl:ENSMUSG00000029916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mulk; AI465370; 2610037M15Rik; 6720408I04Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.1), CNS E14 (RPKM 4.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Agk in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (40302010..40378723)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (40325076..40397570)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (40275477..40346761)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene transmembrane protein 178B Neighboring gene DENN domain containing 11 Neighboring gene WEE1 homolog 2 (S. pombe) Neighboring gene single-stranded DNA binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dihydroceramide kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acylglycerol kinase, mitochondrial
    Names
    multi-substrate lipid kinase
    multiple substrate lipid kinase
    NP_076027.1
    XP_006506634.1
    XP_011239760.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023538.2NP_076027.1  acylglycerol kinase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_076027.1

      Status: VALIDATED

      Source sequence(s)
      AC153728
      Consensus CDS
      CCDS20027.1
      UniProtKB/Swiss-Prot
      Q9ESW4
      Related
      ENSMUSP00000031977.9, ENSMUST00000031977.12
      Conserved Domains (1) summary
      pfam00781
      Location:62195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      40302010..40378723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241458.3XP_011239760.1  acylglycerol kinase, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00781
      Location:62182
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_006506571.4XP_006506634.1  acylglycerol kinase, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam00781
      Location:1102
      DAGK_cat; Diacylglycerol kinase catalytic domain
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