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    Mrto4 mRNA turnover 4, ribosome maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 69902, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mrto4provided by MGI
    Official Full Name
    mRNA turnover 4, ribosome maturation factorprovided by MGI
    Primary source
    MGI:MGI:1917152
    See related
    Ensembl:ENSMUSG00000028741 Vega:OTTMUSG00000009954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrt4; Mg684; 2610012O22Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.0), liver E14 (RPKM 24.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mrto4 in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (139347440..139352576, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (138903360..138908213, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene PQ loop repeat containing 2 Neighboring gene aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase) Neighboring gene cyclin D3, pseudogene Neighboring gene ER membrane protein complex subunit 1 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mRNA turnover protein 4 homolog
    Names
    MRT4, mRNA turnover 4, homolog
    mRNA turnover 4, homolog
    muscle protein684
    ribosome assembly factor Mrto4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290810.1NP_001277739.1  mRNA turnover protein 4 homolog isoform 1

      See identical proteins and their annotated locations for NP_001277739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK011387, BC096556, BY083288, BY246960
      Consensus CDS
      CCDS71505.1
      UniProtKB/Swiss-Prot
      Q9D0I8
      UniProtKB/TrEMBL
      A2AMU9
      Related
      ENSMUSP00000099561.3, OTTMUSP00000010544, ENSMUST00000102503.9, OTTMUST00000023116
      Conserved Domains (1) summary
      cd05796
      Location:21183
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
    2. NM_001356476.1NP_001343405.1  mRNA turnover protein 4 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK011387, AL807811, BC096556, BY083288, BY246960
      Conserved Domains (1) summary
      cd05796
      Location:1136
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
    3. NM_023536.3NP_076025.1  mRNA turnover protein 4 homolog isoform 2

      See identical proteins and their annotated locations for NP_076025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AK011387, BC096556, BY083288, BY246960
      Consensus CDS
      CCDS18845.1
      UniProtKB/Swiss-Prot
      Q9D0I8
      UniProtKB/TrEMBL
      A2AMV1
      Related
      ENSMUSP00000030513.6, OTTMUSP00000010545, ENSMUST00000030513.12, OTTMUST00000023117
      Conserved Domains (1) summary
      cd05796
      Location:21183
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      139347440..139352576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539162.2XP_006539225.1  mRNA turnover protein 4 homolog isoform X1

      Conserved Domains (1) summary
      cd05796
      Location:1136
      Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...
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