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    Med6 mediator complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 69792, updated on 17-Aug-2021

    Summary

    Official Symbol
    Med6provided by MGI
    Official Full Name
    mediator complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1917042
    See related
    Ensembl:ENSMUSG00000002679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU019660; AV213303; 1500012F11Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 20.3), placenta adult (RPKM 18.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Med6 in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81620331..81641782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81573557..81595008, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (82674551..82695945, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20498 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene ragulator complex protein LAMTOR2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 6
    Names
    mediator of RNA polymerase II transcription, subunit 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347384.1NP_001334313.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83983.1
      UniProtKB/Swiss-Prot
      Q921D4
      Related
      ENSMUSP00000125156.2, ENSMUST00000161211.8
      Conserved Domains (1) summary
      pfam04934
      Location:13140
      Med6; MED6 mediator sub complex component
    2. NM_001347385.1NP_001334314.1  mediator of RNA polymerase II transcription subunit 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus], compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83982.1
      UniProtKB/TrEMBL
      E0CYA6
      Related
      ENSMUSP00000124361.2, ENSMUST00000161598.8
    3. NM_001347386.1NP_001334315.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS26023.1
      UniProtKB/Swiss-Prot
      Q921D4
      UniProtKB/TrEMBL
      A0A0R4IZX3
      Related
      ENSMUSP00000002756.8, ENSMUST00000002756.14

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81620331..81641782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027213.2: Suppressed sequence

      Description
      NM_027213.2: This RefSeq was removed because the transcript does not extend far enough 5' to include the start codon.
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