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    Med6 mediator complex subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 69792, updated on 2-Oct-2018

    Summary

    Official Symbol
    Med6provided by MGI
    Official Full Name
    mediator complex subunit 6provided by MGI
    Primary source
    MGI:MGI:1917042
    See related
    Ensembl:ENSMUSG00000002679 Vega:OTTMUSG00000034947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU019660; AV213303; 1500012F11Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 20.3), placenta adult (RPKM 18.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See Med6 in Genome Data Viewer
    Location:
    12; 12 D1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (81573563..81595066, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (82674551..82695945, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene 20498 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene tetratricopeptide repeat domain 9 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 6
    Names
    mediator of RNA polymerase II transcription, subunit 6 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347384.1NP_001334313.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83983.1
      UniProtKB/Swiss-Prot
      Q921D4
    2. NM_001347385.1NP_001334314.1  mediator of RNA polymerase II transcription subunit 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus], compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS83982.1
      UniProtKB/TrEMBL
      E0CYA6
    3. NM_001347386.1NP_001334315.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning results in translation initiation at the downstream start codon to encode an isoform (3) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154908, CK620521, DV651747
      Consensus CDS
      CCDS26023.1
      UniProtKB/Swiss-Prot
      Q921D4
      UniProtKB/TrEMBL
      A0A0R4IZX3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      81573563..81595066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516213.3XP_006516276.1  mediator of RNA polymerase II transcription subunit 6 isoform X3

      Related
      ENSMUSP00000124361.1, OTTMUSP00000048488, ENSMUST00000161598.7, OTTMUST00000088851
      Conserved Domains (1) summary
      pfam04934
      Location:13139
      Med6; MED6 mediator sub complex component
    2. XM_006516211.3XP_006516274.1  mediator of RNA polymerase II transcription subunit 6 isoform X1

      Related
      ENSMUSP00000125156.1, OTTMUSP00000048486, ENSMUST00000161211.7, OTTMUST00000088848
      Conserved Domains (1) summary
      pfam04934
      Location:13139
      Med6; MED6 mediator sub complex component
    3. XM_017315178.1XP_017170667.1  mediator of RNA polymerase II transcription subunit 6 isoform X2

      Conserved Domains (1) summary
      pfam04934
      Location:188
      Med6; MED6 mediator sub complex component

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027213.2: Suppressed sequence

      Description
      NM_027213.2: This RefSeq was removed because the transcript does not extend far enough 5' to include the start codon.
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