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    Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 69721, updated on 16-Oct-2021

    Summary

    Official Symbol
    Nkiras1provided by MGI
    Official Full Name
    NFKB inhibitor interacting Ras-like protein 1provided by MGI
    Primary source
    MGI:MGI:1916971
    See related
    Ensembl:ENSMUSG00000021772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KBRAS1; kappaB-Ras1; 2400004O09Rik
    Expression
    Broad expression in cortex adult (RPKM 13.7), cerebellum adult (RPKM 13.3) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nkiras1 in Genome Data Viewer
    Location:
    14; 14 A1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4185693..4198560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18271136..18284003)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (19103656..19116517)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22350 Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene predicted gene, 41098 Neighboring gene ribosomal protein L15 Neighboring gene predicted gene 7084

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Names
    I-kappa-B-interacting Ras-like protein 1
    kappa B-Ras protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316711.1NP_001303640.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154489, AK010285, AK028539, AW490494, BC054390, BY332128
      UniProtKB/Swiss-Prot
      Q8CEC5
      Conserved Domains (1) summary
      cl38936
      Location:8138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001316712.1NP_001303641.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154489, AK028539, AW490494, BC054390, BY114837, BY332128
      UniProtKB/Swiss-Prot
      Q8CEC5
      Conserved Domains (1) summary
      cl21455
      Location:12142
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_023526.4NP_076015.2  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_076015.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154489, AK028539, AW490494, BC054390, BY332128
      Consensus CDS
      CCDS26836.1
      UniProtKB/Swiss-Prot
      Q8CEC5
      Related
      ENSMUSP00000121496.2, ENSMUST00000132374.9
      Conserved Domains (1) summary
      cl38936
      Location:6168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      4185693..4198560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247999.1XP_030103859.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:8138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_036158841.1XP_036014734.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:8138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006518097.5XP_006518160.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006518160.1

      UniProtKB/Swiss-Prot
      Q8CEC5
      Conserved Domains (1) summary
      cl38936
      Location:6168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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