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    Ipmk inositol polyphosphate multikinase [ Mus musculus (house mouse) ]

    Gene ID: 69718, updated on 26-Jul-2021

    Summary

    Official Symbol
    Ipmkprovided by MGI
    Official Full Name
    inositol polyphosphate multikinaseprovided by MGI
    Primary source
    MGI:MGI:1916968
    See related
    Ensembl:ENSMUSG00000060733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Impk; AA408208; 2410017C19Rik
    Expression
    Broad expression in small intestine adult (RPKM 30.9), colon adult (RPKM 26.8) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Ipmk in Genome Data Viewer
    Location:
    10; 10 B5.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (71183574..71221715)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (71347744..71385885)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (70810541..70848633)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19, pseudogene 2 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene proteolipid protein 2 pseudogene Neighboring gene predicted gene, 34486

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavonoid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol tetrakisphosphate 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol tetrakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol tetrakisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol tetrakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-1,4,5-trisphosphate 6-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inositol polyphosphate multikinase
    Names
    inositol 1,3,4,6-tetrakisphosphate 5-kinase
    NP_001334120.1
    NP_081460.1
    XP_011241857.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347191.2NP_001334120.1  inositol polyphosphate multikinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1.
      Source sequence(s)
      AC156270
      Consensus CDS
      CCDS83711.1
      UniProtKB/Swiss-Prot
      Q7TT16
      UniProtKB/TrEMBL
      D3YWA2
      Related
      ENSMUSP00000112568.2, ENSMUST00000121446.2
    2. NM_027184.3NP_081460.1  inositol polyphosphate multikinase isoform 1

      See identical proteins and their annotated locations for NP_081460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1).
      Source sequence(s)
      AC156270
      Consensus CDS
      CCDS23918.1
      UniProtKB/Swiss-Prot
      Q7TT16
      Related
      ENSMUSP00000078240.7, ENSMUST00000079252.13
      Conserved Domains (1) summary
      pfam03770
      Location:110391
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      71183574..71221715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243555.2XP_011241857.1  inositol polyphosphate multikinase isoform X1

      Conserved Domains (1) summary
      cl12283
      Location:111194
      IPK; Inositol polyphosphate kinase
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