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    Clybl citrate lyase beta like [ Mus musculus (house mouse) ]

    Gene ID: 69634, updated on 12-Aug-2018

    Summary

    Official Symbol
    Clyblprovided by MGI
    Official Full Name
    citrate lyase beta likeprovided by MGI
    Primary source
    MGI:MGI:1916884
    See related
    Ensembl:ENSMUSG00000025545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clb; AI256068; 0610033J05Rik; 2310014M14Rik
    Expression
    Broad expression in kidney adult (RPKM 9.1), heart adult (RPKM 8.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See Clybl in Genome Data Viewer
    Location:
    14; 14 E5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (122171283..122402234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (122580916..122801456)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene predicted gene 5089 Neighboring gene RIKEN cDNA 2610035F20 gene Neighboring gene predicted gene, 33719 Neighboring gene zinc finger protein of the cerebellum 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    (3S)-citramalyl-CoA lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    (3S)-citramalyl-CoA lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    (3S)-citramalyl-CoA lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    malate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cobalamin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cobalamin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cobalamin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    citramalyl-CoA lyase, mitochondrial; citrate lyase subunit beta-like protein, mitochondrial
    Names
    beta-methylmalate synthase
    malate synthase
    NP_083832.2
    XP_011243474.1
    XP_011243475.1
    XP_011243476.1
    XP_011243477.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029556.3NP_083832.2  citramalyl-CoA lyase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083832.2

      Status: VALIDATED

      Source sequence(s)
      AC164315, AK009345, CX202248
      Consensus CDS
      CCDS27346.1
      UniProtKB/Swiss-Prot
      Q8R4N0
      Related
      ENSMUSP00000026625.5, ENSMUST00000026625.6
      Conserved Domains (1) summary
      COG2301
      Location:45335
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      122171283..122402234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245173.2XP_011243475.1  citrate lyase subunit beta-like protein, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG2301
      Location:29291
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]
    2. XM_011245172.2XP_011243474.1  citrate lyase subunit beta-like protein, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG2301
      Location:45307
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]
    3. XM_011245174.2XP_011243476.1  citrate lyase subunit beta-like protein, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG2301
      Location:1176
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]
    4. XM_011245175.2XP_011243477.1  citrate lyase subunit beta-like protein, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl21481
      Location:1146
      malate_synt; Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their ...
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