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    Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 [ Mus musculus (house mouse) ]

    Gene ID: 69632, updated on 31-Jan-2019

    Summary

    Official Symbol
    Arhgef12provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 12provided by MGI
    Primary source
    MGI:MGI:1916882
    See related
    Ensembl:ENSMUSG00000059495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Larg; AU019857; mKIAA0382; 2310014B11Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 23.6), kidney adult (RPKM 17.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Arhgef12 in Genome Data Viewer
    Location:
    9; 9 A5.1
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (42963842..43105718, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (42771925..42913801, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590 Neighboring gene predicted gene, 36648 Neighboring gene Sp140 nuclear body protein family member pseudogene Neighboring gene transmembrane protein 136 Neighboring gene POU domain, class 2, transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0380

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rho guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 12
    Names
    leukemia-associated Rho guanine-nucleotide exchange factor
    leukemia-associated RhoGEF

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359232.1NP_001346161.1  rho guanine nucleotide exchange factor 12 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a three-nucleotide segment in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC110169, AC160123
      Conserved Domains (4) summary
      cd08754
      Location:349570
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:791976
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:71145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:9951132
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    2. NM_027144.2NP_081420.2  rho guanine nucleotide exchange factor 12 isoform 1

      See identical proteins and their annotated locations for NP_081420.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC110169, AC160123
      Consensus CDS
      CCDS40595.1
      UniProtKB/TrEMBL
      F8VQN6
      Related
      ENSMUSP00000126598.1, ENSMUST00000165665.8
      Conserved Domains (4) summary
      cd08754
      Location:350571
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:71145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:9961133
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:792977
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      42963842..43105718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313567.1XP_017169056.1  rho guanine nucleotide exchange factor 12 isoform X5

    2. XM_011242598.2XP_011240900.1  rho guanine nucleotide exchange factor 12 isoform X6

      Conserved Domains (3) summary
      cd08754
      Location:182403
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd13390
      Location:828965
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:624809
      RhoGEF; RhoGEF domain
    3. XM_017313565.1XP_017169054.1  rho guanine nucleotide exchange factor 12 isoform X2

    4. XM_011242597.1XP_011240899.1  rho guanine nucleotide exchange factor 12 isoform X4

      Conserved Domains (4) summary
      cd08754
      Location:330551
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:52126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:9761113
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:772957
      RhoGEF; RhoGEF domain
    5. XM_017313566.1XP_017169055.1  rho guanine nucleotide exchange factor 12 isoform X3

    6. XM_006510586.3XP_006510649.1  rho guanine nucleotide exchange factor 12 isoform X1

      UniProtKB/Swiss-Prot
      Q8R4H2
      Related
      ENSMUSP00000072547.6, ENSMUST00000072767.6
      Conserved Domains (4) summary
      cd08754
      Location:349570
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:791976
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:71145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:9951132
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
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