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    Afg3l2 AFG3-like AAA ATPase 2 [ Mus musculus (house mouse) ]

    Gene ID: 69597, updated on 31-Jan-2019

    Summary

    Official Symbol
    Afg3l2provided by MGI
    Official Full Name
    AFG3-like AAA ATPase 2provided by MGI
    Primary source
    MGI:MGI:1916847
    See related
    Ensembl:ENSMUSG00000024527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    par; Emv66; AW260507; 2310036I02Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 22.4), adrenal adult (RPKM 20.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Afg3l2 in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (67404760..67449136, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (67564418..67608790, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B430212C06 gene Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector A Neighboring gene tubulin, beta 6 class V Neighboring gene predicted gene, 46621 Neighboring gene PRELI domain containing 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    paralyse
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cristae formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial protein processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autoprocessing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    righting reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    m-AAA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    AFG3-like protein 2
    Names
    AFG3 (ATPase family gene 3)-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027130.2NP_081406.1  AFG3-like protein 2

      See identical proteins and their annotated locations for NP_081406.1

      Status: VALIDATED

      Source sequence(s)
      AK168668, BC043056
      Consensus CDS
      CCDS37847.1
      UniProtKB/Swiss-Prot
      Q8JZQ2
      Related
      ENSMUSP00000025408.8, ENSMUST00000025408.8
      Conserved Domains (4) summary
      TIGR01241
      Location:252745
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:344475
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:561743
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:145241
      FtsH_ext; FtsH Extracellular

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      67404760..67449136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246998.1XP_011245300.1  AFG3-like protein 2 isoform X1

      Conserved Domains (4) summary
      TIGR01241
      Location:174667
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:266397
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:483665
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:67163
      FtsH_ext; FtsH Extracellular
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