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    Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69568, updated on 23-Jun-2021

    Summary

    Official Symbol
    Vkorc1l1provided by MGI
    Official Full Name
    vitamin K epoxide reductase complex, subunit 1-like 1provided by MGI
    Primary source
    MGI:MGI:1916818
    See related
    Ensembl:ENSMUSG00000066735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310024K08Rik
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 7.6), CNS E18 (RPKM 7.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Vkorc1l1 in Genome Data Viewer
    Location:
    5; 5 G1.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129970950..130015533)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129942109..129986692)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (130417983..130458761)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED type containing 5 Neighboring gene nuclear protein transcriptional regulator 1 like Neighboring gene glucuronidase, beta Neighboring gene argininosuccinate lyase Neighboring gene predicted gene, 40334

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin-K-epoxide reductase (warfarin-sensitive) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-glutamic acid carboxylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-glutamic acid carboxylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin K metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vitamin K metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vitamin K epoxide reductase complex subunit 1-like protein 1
    Names
    VKORC1-like protein 1
    NP_001001327.1
    NP_001273311.1
    NP_081397.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001327.2NP_001001327.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001001327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470
      Consensus CDS
      CCDS19704.1
      UniProtKB/TrEMBL
      Q0VGU5
      Related
      ENSMUSP00000144608.2, ENSMUST00000201855.2
      Conserved Domains (1) summary
      cl01729
      Location:1865
      VKOR; Vitamin K epoxide reductase (VKOR) family
    2. NM_001286382.1NP_001273311.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
      Consensus CDS
      CCDS80417.1
      UniProtKB/TrEMBL
      A0A0M3HEP8, Q0VGU5
      Related
      ENSMUSP00000073601.6, ENSMUST00000073945.6
      Conserved Domains (1) summary
      cd12917
      Location:19110
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants
    3. NM_027121.4NP_081397.1  vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK033702, AK078942, BC085133, BE954096, CF533903, CK639505, CN457470, CN701203
      Consensus CDS
      CCDS19703.1
      UniProtKB/Swiss-Prot
      Q6TEK5
      UniProtKB/TrEMBL
      Q0VGU5
      Related
      ENSMUSP00000059139.9, ENSMUST00000051758.11
      Conserved Domains (1) summary
      cd12917
      Location:18156
      VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129970950..130015533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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