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    Cdk13 cyclin-dependent kinase 13 [ Mus musculus (house mouse) ]

    Gene ID: 69562, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk13provided by MGI
    Official Full Name
    cyclin-dependent kinase 13provided by MGI
    Primary source
    MGI:MGI:1916812
    See related
    Ensembl:ENSMUSG00000041297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc2l5; 2310015O17Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.0), thymus adult (RPKM 8.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk13 in Genome Data Viewer
    Location:
    13; 13 A2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (17715962..17805097, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (17807796..17896931, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene succinyl-CoA glutarate-CoA transferase Neighboring gene predicted gene, 40826 Neighboring gene M-phase specific PLK1 intereacting protein Neighboring gene microRNA 466i Neighboring gene predicted gene, 18859 Neighboring gene ADP-ribosylation factor 3 pseudogene Neighboring gene v-ral simian leukemia viral oncogene A (ras related)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation of RNA polymerase II C-terminal domain ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription elongation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin K-CDK13 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-dependent kinase 13
    Names
    CDC2-related protein kinase 5
    cell division cycle 2-like 5 (cholinesterase-related cell division controller)
    cell division cycle 2-like protein kinase 5
    cell division protein kinase 13
    NP_001074527.1
    NP_081394.1
    XP_006516829.1
    XP_006516830.1
    XP_011242646.1
    XP_017171082.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081058.2NP_001074527.1  cyclin-dependent kinase 13 isoform 1

      See identical proteins and their annotated locations for NP_001074527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154219, AC154828
      Consensus CDS
      CCDS36604.1
      UniProtKB/Swiss-Prot
      Q69ZA1
      Related
      ENSMUSP00000036013.7, ENSMUST00000042365.8
      Conserved Domains (2) summary
      smart00220
      Location:705994
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:697998
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. NM_027118.1NP_081394.1  cyclin-dependent kinase 13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC154219, AC154828
      UniProtKB/Swiss-Prot
      Q69ZA1
      Related
      ENSMUSP00000152820.1, ENSMUST00000223490.1
      Conserved Domains (2) summary
      smart00220
      Location:705994
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:697998
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      17715962..17805097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244344.2XP_011242646.1  cyclin-dependent kinase 13 isoform X4

      Related
      ENSMUSP00000152539.1, ENSMUST00000222800.1
      Conserved Domains (2) summary
      smart00220
      Location:91380
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:83384
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    2. XM_006516767.3XP_006516830.1  cyclin-dependent kinase 13 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:705994
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:697998
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    3. XM_006516766.3XP_006516829.1  cyclin-dependent kinase 13 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:705994
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:697998
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
    4. XM_017315593.1XP_017171082.1  cyclin-dependent kinase 13 isoform X3

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