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    Nup35 nucleoporin 35 [ Mus musculus (house mouse) ]

    Gene ID: 69482, updated on 12-Aug-2018

    Summary

    Official Symbol
    Nup35provided by MGI
    Official Full Name
    nucleoporin 35provided by MGI
    Primary source
    MGI:MGI:1916732
    See related
    Ensembl:ENSMUSG00000026999 Vega:OTTMUSG00000018807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MP44; NO44; 35kDa; 2310006I24Rik; 5330402E05Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 15.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nup35 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (80638812..80660071)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (80478969..80500228)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13688 Neighboring gene dual specificity phosphatase 19 Neighboring gene microRNA 684-1 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene predicted gene, 36282 Neighboring gene putative Eno1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Targeted (2) 
    • Chemically induced (ENU) (1)  1 citation

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear lamina ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear pore nuclear basket IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nucleoporin NUP35
    Names
    35 kDa nucleoporin
    mitotic phosphoprotein 44
    nuclear pore complex protein Nup53

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190179.1NP_001177108.1  nucleoporin NUP35 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR/coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK136109, AK145775, CA560987, DV653588
      UniProtKB/Swiss-Prot
      Q8R4R6
      Conserved Domains (1) summary
      cd12722
      Location:154227
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53
    2. NM_027091.4NP_081367.1  nucleoporin NUP35 isoform 1

      See identical proteins and their annotated locations for NP_081367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK136109, AK145775, BY272877
      Consensus CDS
      CCDS16179.1
      UniProtKB/Swiss-Prot
      Q8R4R6
      Related
      ENSMUSP00000028382.6, OTTMUSP00000014349, ENSMUST00000028382.12, OTTMUST00000032318
      Conserved Domains (1) summary
      cd12722
      Location:171244
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      80638812..80660071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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