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    Elf2 E74-like factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 69257, updated on 2-Oct-2018

    Summary

    Official Symbol
    Elf2provided by MGI
    Official Full Name
    E74-like factor 2provided by MGI
    Primary source
    MGI:MGI:1916507
    See related
    Ensembl:ENSMUSG00000037174 Vega:OTTMUSG00000051593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EU32; NERF; NERF-2; NERF-1A; NERF-1B; AW111824; BB183398; 2610036A20Rik; A230104O07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 16.4), thymus adult (RPKM 9.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Elf2 in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (51252720..51340920, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (51059587..51129909, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40044 Neighboring gene nocturnin Neighboring gene RIKEN cDNA 4930577N17 gene Neighboring gene nuclear encoded tRNA proline 7 (anticodon TGG) Neighboring gene nuclear encoded tRNA proline 5 (anticodon AGG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-2
    Names
    ets domain transcription factor
    ets family transcription factor ELF2A2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291059.1NP_001277988.1  ETS-related transcription factor Elf-2 isoform 2

      See identical proteins and their annotated locations for NP_001277988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AK146819
      Consensus CDS
      CCDS71242.1
      UniProtKB/Swiss-Prot
      Q9JHC9
      UniProtKB/TrEMBL
      Q3TVH6
      Related
      ENSMUSP00000061076.6, OTTMUSP00000069818, ENSMUST00000062009.13, OTTMUST00000130178
      Conserved Domains (2) summary
      pfam00178
      Location:198277
      Ets; Ets-domain
      pfam12310
      Location:3108
      Elf-1_N; Transcription factor protein N terminal
    2. NM_001291062.1NP_001277991.1  ETS-related transcription factor Elf-2 isoform 3

      See identical proteins and their annotated locations for NP_001277991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure and an alternate splice site in the coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AF256218
      Consensus CDS
      CCDS71240.1
      UniProtKB/Swiss-Prot
      Q9JHC9
      Related
      ENSMUSP00000103686.1, OTTMUSP00000023464, ENSMUST00000108051.7, OTTMUST00000050298
      Conserved Domains (2) summary
      pfam00178
      Location:138217
      Ets; Ets-domain
      pfam12310
      Location:2048
      Elf-1_N; Transcription factor protein N terminal
    3. NM_001291063.1NP_001277992.1  ETS-related transcription factor Elf-2 isoform 4

      See identical proteins and their annotated locations for NP_001277992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' structure compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC118601, AC161183, AF256219
      Consensus CDS
      CCDS71241.1
      UniProtKB/Swiss-Prot
      Q9JHC9
      Related
      ENSMUSP00000103688.2, OTTMUSP00000023463, ENSMUST00000108053.8, OTTMUST00000050297
      Conserved Domains (2) summary
      pfam00178
      Location:150229
      Ets; Ets-domain
      pfam12310
      Location:2048
      Elf-1_N; Transcription factor protein N terminal
    4. NM_001356358.1NP_001343287.1  ETS-related transcription factor Elf-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC118601, AC161183
      Conserved Domains (2) summary
      smart00413
      Location:116198
      ETS; erythroblast transformation specific domain
      pfam12310
      Location:429
      Elf-1_N; Transcription factor protein N terminal
    5. NM_023502.2NP_075991.1  ETS-related transcription factor Elf-2 isoform 1

      See identical proteins and their annotated locations for NP_075991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC118601, AC161183, AF256217
      Consensus CDS
      CCDS17337.1
      UniProtKB/Swiss-Prot
      Q9JHC9
      Related
      ENSMUSP00000141197.1, OTTMUSP00000023461, ENSMUST00000194641.5, OTTMUST00000050295
      Conserved Domains (2) summary
      pfam00178
      Location:210289
      Ets; Ets-domain
      pfam12310
      Location:3108
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      51252720..51340920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319713.1XP_017175202.1  ETS-related transcription factor Elf-2 isoform X2

      Conserved Domains (2) summary
      smart00413
      Location:116198
      ETS; erythroblast transformation specific domain
      pfam12310
      Location:429
      Elf-1_N; Transcription factor protein N terminal
    2. XM_006502031.3XP_006502094.1  ETS-related transcription factor Elf-2 isoform X1

      See identical proteins and their annotated locations for XP_006502094.1

      Conserved Domains (2) summary
      pfam00178
      Location:131210
      Ets; Ets-domain
      pfam12310
      Location:229
      Elf-1_N; Transcription factor protein N terminal
    3. XM_017319714.1XP_017175203.1  ETS-related transcription factor Elf-2 isoform X3

      Conserved Domains (1) summary
      pfam00178
      Location:106185
      Ets; Ets-domain
    4. XM_011240222.2XP_011238524.1  ETS-related transcription factor Elf-2 isoform X4

      Conserved Domains (1) summary
      pfam00178
      Location:94173
      Ets; Ets-domain
    5. XM_006502034.3XP_006502097.1  ETS-related transcription factor Elf-2 isoform X5

      See identical proteins and their annotated locations for XP_006502097.1

      Conserved Domains (1) summary
      pfam00178
      Location:75154
      Ets; Ets-domain
    6. XM_006502035.3XP_006502098.1  ETS-related transcription factor Elf-2 isoform X5

      See identical proteins and their annotated locations for XP_006502098.1

      Conserved Domains (1) summary
      pfam00178
      Location:75154
      Ets; Ets-domain
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